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Reformulation of a product through the addition of a novel drug delivery system is a highly effective method to prolong a drug's revenue-generating life and provide new competitive advantages that may sustain or increase sales or halt a decline in market sales. Loss of a blockbuster drug due to patent expiration can be devastating to a product's sales. For example, sales of Bristol-Myers Squibb's Capten captopril ; fell 83% from US$146 million to US$25 million in the 12 months following its 1996 patent expiration. Merck's Vasotec enalapril ; lost more than 80% of it market share within three months of patent expiration. Perhaps the most dramatic example was in 2001 when more than 65% of Eli Lilly's Prozac sales were converted to generic sales in the first month after patent expiration.5 Table 3 outlines the 2001 sales of blockbuster drugs slated to expire from 2001 to 2010.6. A dry powder inhaler is a device designed for breathing powdered medicine into the lungs without using an aerosol propellant. Drug makers offer inhaler medicine as powders, because some aerosol propellants harm the earth's ozone layer. Eventually, metered-dose inhalers with chlorofluorocarbon propellant will not be available. Several types of dry powder inhalers are available, and each requires a slightly different technique.

From the Departments of Radiology N.O., N.E. ; and General Surgery C.K., E.O. ; , Erciyes University Faculty of Medicine, 38039-Kayseri, Turkey. Presented at the Cardiovascular and Interventional Radiology Society of Europe Meeting, Gothenburg, 2001. Received August 10, 2002; accepted October 24. Address correspondence to N.O.; E-mail: nevzatcan yahoo None of the authors has identified a potential conflict of interest. SIR, 2003 DOI: 10.1097, because bristol myers squibb.

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AEGiS - the longest established and largest global resource of online HIV information - includes HTB in the regular journals that it puts online. You can find us at: : aegis pubs i-base 2004 The AEGiS daily email news service also carries i-Base conference reports.
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Study phase I: daily supplementation with synthetic vitamin K Dose-response for coagulation parameters The coagulation changes in response to each weekly incremental K1 dose in the 12 subjects mean SD ; are shown in Table 3. The INR data represent the 7 day means of the 4 weekly INR values obtained on Tuesday 24 h after the change in K1 dose ; , Wednesday, Friday and the following Monday i.e. 7 days; immediately before the change in K1 dose ; . For FIIc and FVIIc the values were the means of two measurements after 24 h Tuesday ; and 7 days Monday ; . INR values decreased dose-dependently as the dose of vitamin K increased but the difference of the 7-day mean from baseline adjustment phase ; only became statistically significant when the K1 supplement dose had reached 150 g day in women and 200 g day in men. When the change in INR from baseline was analyzed individually, a statistically significant response was found for one woman 57 kg ; after the K1 dose had reached 100 g day. In parallel to the fall in INR, both FIIc and FVIIc rose with increasing vitamin K intake, and the 7-day mean response was statistically significant from baseline at K1 doses of 150 g day for FIIc and 200 g day for FVIIc. An inverse correlation was found between the INR and FIIc r2 -0.891, p 0.001 ; and between the INR and FVIIc r2 -0.823, p 0.001 ; . Figure 1A shows the mean changes in INR for all subjects plotted in a logarithmic scale of vitamin K1 dose. The resultant curves were typical of the sigmoid log dose-response curves found for many agonist-antagonist interactions. Interestingly, the changes in INR after 24 h were similar to those obtained after the entire 7-day period mean of 4 INR values ; . Since the INR is a hybrid measurement we also examined the response for the individual proteins FIIc and FVIIc. The 7-day mean change for FIIc is shown in Figure 1B and again shows a clear sigmoidal dose-response relationship. The dose-response curve for FVIIc not shown ; was less clear probably reflecting the much wider inter-individual variation Table 3 ; . In summary, the response curves indicate a slow increase in coagulation factors for supplemental K1 intakes up to 100 g, an approximate log-linear and cilostazol.
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In phase iii, large-scale, multi-center, adequate and well-controlled, comparative clinical trials are conducted with patients in order to provide enough data for the statistical proof of efficacy and safety required by the fda and others, however in some limited circumstances phase iii trials may be modified to allow evaluation of safety and efficacy in a less regimented manner, which may allow the company to rely on historical data relating to the previous use of certain pharmaceuticals and clobetasol.
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A person with PD should receive treatment from a multidisciplinary team, the members of which can advise on all types of therapy, community home services and drug treatment. There are many effective drug treatments that can control the symptoms of PD, although in the early stages of PD people may experience excellent control of symptoms with only minimal doses of medication, and little intervention from doctors. `ON time' is a period when symptoms are responding well to medication. `OFF time' is a period when symptoms are responding poorly to medication.
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Attempts at using renal scmtigraphy to diagnose renal artery stenosis RAS ; were disappointing. Renal scintigraphy with 1-131 iodohippurate had a sensitivity and specificity of only 80%-85% 1, 2 ; . Recently, many investigators have evaluated the use of captopnil Capoten; Squibb Diagnostics, Princeton, NJ ; in conjunction with renal scintigraphy. Captopnil, an angiotensin-converting enzyme inhibitor, has the theoretical advantage of improving the sensitivity and specificity of renal scintigraphy for enabling detection of RAS and cutivate.

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