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These targeting molecules it is possible to create a molecule that will kill only harmful T cells, leaving helpful T cells unaffected, and by choosing a toxin that can only work once internalised by the T cell, harmful side effects should also be avoided. Molecules capable of killing harmful T cells are likely to have uses in clinical medicine as well as experimental biology. In solid organ transplants they could be used to prevent the recipient rejecting the new organ. In transplantation they may allow the depletion of T cells likely to cause graftversus-host disease from donor bone marrow, using a closed bag system that will not require further manipulation before infusion. In autoimmune disease they may be useful as drugs to kill harmful T cells already active in the patient. In experimental biology they may allow depletion of specific T cells from a mixed sample of cells, in order to measure the impact of those T cells in an experimental system. This exciting technology therefore has a wide range of applications and could prove to be a major advance in the treatment of unwanted immune reactions.
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R.M. Sawaya and D.S. Riddick Department of Pharmacology, University of Toronto, Toronto, Ontario, M5S 1A8. rana.sawaya utoronto Aromatic hydrocarbons AHs ; , such as 3-methylcholanthrene MC ; , elicit toxic and adaptive responses via the aryl hydrocarbon receptor AHR ; . AHs suppress the transcription of the growth hormone-regulated, male-specific rat hepatic cytochrome P450 2C11 gene CYP2C11 ; via an unknown mechanism. Structure-activity analysis suggests the involvement of the AHR in CYP2C11 suppression. We hypothesize that the in vivo suppression of CYP2C11 by AHs is mediated by the gene's promoter and 5'flanking region. Following bioinformatic analysis of putative transcription factor TF ; binding sites, we cloned various lengths up to 10kb ; of the CYP2C11 5'-flank into a promoterless luciferase plasmid. Using high-volume tail vein injections to deliver plasmid to the liver of live rats, we studied the AH-responsiveness of luciferase constructs containing 10.1-kb and 2.4-kb of the CYP2C11 5'-flank. MC treatment suppressed CYP2C11-driven luciferase activity of the 10.1-kb construct to 48% of control levels by 24h and to 31% by 72h after treatment. The luciferase activity of the construct containing 2.4-kb of the CYP2C11 5'-flank was not suppressed by MC indicating that negative regulatory element s ; responsible for CYP2C11 reporter suppression by MC exist between -10.1 and -2.4-kb. Trends for corresponding decreases of endogenous CYP2C11 protein and mRNA were detected by immunoblotting and real-time PCR; however, this did not always reach statistical significance. As a positive control for AHR activation, MC dramatically induced the luciferase activity of a Cyp1a1-driven luciferase plasmid under AHR control. This is the first demonstration of the suppression of a CYP2C11 luciferase construct by an AH and this finding suggests that the 5'-flanking region and promoter mediates the down-regulation of this gene in the intact rat. [Support: CIHR] and elavil.
The reimbursement level, which is on average 65% of price paid by the customer, is due to change by mid-2003. The major change is that the generic price level always 30% less than the brand name product ; will become the reference price for the 65% reimbursement level. This change will allow generics to increase their market share from 4% to 15-20% of the French non-hospital pharmaceutical market. Enhanced generic substitution is also being demanded of doctors as a pay-off for the recent increase in consultation fees. The de-listing of 800 reimbursed drugs mainly vein tonics ; on risk-benefit grounds is expected in the coming three years. On the positive side, incentives are promised for new innovative products. Clin chem 9-502, 197 1 roberts wc: the rule of 5 and the rule of 7 in lipid-lowering by statin drugs and endep, for example, atrial fibrillation. 2003; 1 -4 source procter & gamble 01 17 2007 contact: corporate media center, + 1-866-procter, + 1-866-776-2837 elaine plummer, p&g pharmaceuticals, inc, + 1-513-622-3662 8777 01 est site 2006 procter & gamble.

The authors thank Cleopatra Alvaro, Ryan Descallar, Leo Angelo Ocampo, Gloria Oracoy and Florence Tolentino for their invaluable contribution to data collection and data processing, and Josephine Parinas for administrative assistance. Also, the authors thank the Department of Health of the Philippines for endorsing the project, and the directors and staff of the Central and Regional Hospital Licensing Units of the Department of Health for their assistance with data access. This research is supported by The David and Lucile Packard Foundation. The findings and conclusions expressed are entirely those of the authors, and do not necessarily represent the views of The David and Lucile Packard Foundation and caduet. You simply can't always trust your doctor to inform you. Because no busy person could possibly remember how over 1, 000 drugs interact with each other. That's the simple, unfortunate and sad truth. Why do you think all doctors carry malpractice insurance? ; A new book, 1, Prescription Drugs, will tell you everything you need to know about every prescription drug. With each drug conveniently listed in alphabetical order by brand name as well as its pharmaceutical name, you will discover little-known facts about each drug . how to take it . possible side effects . possible interactions with other drugs . and other important information you may never learn from your doctor or pharmacist.
To achieve the overall goal of eliminating unsafe abortion, the participants at the consultation identified priority topics and activities in research, capacitybuilding, norms and tools, and advocacy to reduce the burden of unsafe abortion on women, their families, and health systems. The participants made recommendations in four main areas: 1 ; biomedical research and the introduction of medical abortion technologies, 2 ; social, behavioural, and health systems research, 3 ; programmes and policies, and 4 ; advocacy. The participants acknowledged that defining priorities is often a challenge, given that the problems associated with unsafe abortion are subject to shifts in social and legal contexts over a period of time and that, to a greater extent than with many other reproductive health issues, unsafe abortion is a regional matter. This call for action reflects recent thinking on issues associated with unsafe abortion, including topics that are relevant globally or in some cases, for specific regions only and ascorbic.

Leukemia. Until then, this is Dr. Ken Miller from the Yale Cancer Center wishing you a safe and healthy week.
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