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Methods: Eligible pts were those with: a ; recurrent anaplastic oligodendrogliomas AO ; , anaplastic astrocytoma AA ; or glioblastoma multiforme GBM ; , b ; evidence of measurable disease on contrast-enhanced MRI, c ; KPS 60, d ; no radiation within the prior 3 months, e ; no chemotherapy within the prior 6 weeks, and f ; adequate baseline hematological, renal and hepatic parameters. An oral dose of 200 mg m 2 was given as an initial bolus followed by nine doses of 90 mg m 2 every 12 hours for a total of 9 doses. Complete blood counts were drawn weekly. Treatment cycles were repeated every 28 days. Response was assessed by contrast-enhanced MRI every 2 cycles. Pts with progressive disease were off the protocol, whereas those with stable disease or better continued receiving the TemodarTM. Results: 16 pts have been enrolled to date 10 M, 6 F ; Median age at the time of treatment was 44 years range 2977 ; . Pathology at diagnosis included: AO 4 ; , AA and GBM 11 ; . 8 pts had received prior chemotherapy: BCNU 5 ; , PCV 2 ; and high-dose thiotepa 1 ; . Of evaluable cycles, grade III-IV leukopenia was noted in 2 pts 5% of cycles grade III-IV thrombocytopenia was seen in 2 pts 8% of cycles ; . Severe toxicities always occurred during the first 2 cycles, requiring dose reductions. Subsequent cycles were uneventful. One pt died from Staph. aureus septicemia. Overall quality of life in the remaining pts was maintained. Grade II nausea was noted in 3 pts following the first dose, but was not observed when antiemetics were instituted prophylactically. Of 10 pts who completed 2 or more cycles, CR was seen in 2 GBM ; , PR in 2 AA, 1 GBM ; , SD in 3 GBM, 1 AO ; , and PD in 3 GBM, 1 AO ; . Conclusions: A bid regimen of temozolomide appears to be well tolerated. Hematologic toxicity was mild, even in those who had been previously treated with chemotherapy. Current response rates are promising. 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For a dependent child of divorced parents with joint custody, if the court decree does not specify which parent is responsible for health care coverage, then Rule "c." above will apply; for a dependent child of separated parents with joint custody, if the court decree does not specify which parent is responsible for health care coverage, then Rule "c." above will apply; a plan which covers an employee and, consequently, his or her dependents ; as an active employee, rather than as a laid-off employee or retired employee, will pay before a plan which covers a laid-off or retired employee. If the other plan does not have this rule, and the plans disagree about the order of benefits, this paragraph is disregarded; if a person is covered under a right of continuation policy as required by the Consolidated Omnibus Reconciliation Act COBRA ; of 1987, as amended, and is also covered under another plan, the following rules will apply: 1. 2. the benefits of a plan covering the person as an employee, member or subscriber or as that person's dependent ; will be primary; the benefits under the continuation coverage will be secondary, for example, trazedone. Pharmaceutical form: chewable, scored tablet, 6 mg Dose: 200g kg body weight single administration Category: macro-cyclic lactone Mode of action: the drug causes the paralysis in many nematodes and arthropods through the influx of chloride ions across cell membranes. Pharmacokinetics: the drug is absorbed into the blood following oral administration and peak levels are reached 4h after oral administration. It is excreted almost entirely in the faeces. Efficacy: few trials investigated the use of ivermectin for the treatment of intestinal helminths. Despite its multitude of uses in veterinary medicine and its activity against various life-cycle stages of many nematodes, in human medicine, its use has been almost exclusively as a microfilaricide for the treatment of onchocerciasis. It is currently licensed in France for the treatment of Strongyloides stercoralis. The drug has been reported to be 100% effective against A. lumbricoides at dosages of 50-200 g kg 4 trials ; , 82-95% effective against S. stercoralis in single or two administration of more than 150 g kg 4 trials ; . 11-100% effective on T. trichiura according to the different dosage used from 200 g kg single dose to 400 g kg in two divided doses with administration over 2 days ; and 0-20% effective on hookworms and mesterolone. 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Evidence based practice guidelines and policies are hard to come by in a large, non-homogenous and mobile population as in dive medicine the mobile population globally lack a common denominator. How to deal with travellers, especially special groups e.g. children, pregnant women - divers ; , so as to able to provide optimal protection against malaria other dive related threats ; to health and safety? The new "Guidelines for the prevention of malaria in South Africa" provide an excellent basis for Health Care Providers. The guideline and its companion publication, the "Guidelines for the treatment of malaria in South Africa" were both produced by the NATIONAL DEPARTMENT OF HEALTH and the MALARIA ADVISORY GROUP's Sub-committee for Chemoprophylaxis and Therapy. Members of the committee come from the public, private and academic sector of the community. No adverse events were noted during the study. Feeding activity in the unchallenged, unmedicated fish Group 1 ; was scored at 2 throughout the study. The average feeding activity score for the challenged, unmedicated fish Group 2 ; was between 0 and 1 from days 4 17, and was consistently 1.5 until day 21. Feeding activity in all FFC-medicated groups was scored at 2 for all days throughout the study, except day 5. On that one day, 2 tanks of fish in Group 3 10 mg FFC kg ; and one tank of fish in Group 5 40 mg FFC kg ; had feeding scores of 1, dropping the group average for that day to 1.5 and 1.75, respectively. At the end of the study period, the average body weight of surviving challenged, untreated fish Group 2 ; was lower than that of surviving FFC-treated fish p 0.05 ; .4 and naprosyn and desyrel, for example, desyrle 200. Select medication based on the type and severity of a patient's acne, as well as the patient's skin type: creams, lotions, or ointments for dry skin; solutions or gels for oily skin. 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