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NITROGEN OXIDES--Contd. Clean Air Act CAA ; --Cement firm charged with emission and permit violations C.D. Cal. ; , 268 --Clark Generating Plant, Nev. Power to clean up D. Nev. ; , 547 --Coal-fired plants, Nev. Power settles nitrogen oxide and other violations D. Nev. ; , 349 Ga. to reduce limits from electric steam-generating units, 126 Ships, emissions standards. See LEGISLATION, FEDERAL, HR 802 Tex., chemical plants charged with failure to prevent hazardous releases Tex. Dist. Ct. ; , 20 NORTH CAROLINA Dry cleaning solvent cleanup law changes approved by state Senate, 631; and state Legislature, 686 Fire at waste storage site, penalty issued, 268 Hazardous waste facilities, state legislature approves tighter requirements, 571 TCE in drinking water, Camp LeJeune family's FTCA suit dismissed S.D. Miss. ; , 694 NORTH DAKOTA Ammonia fumes released by train derailment, settlement approved D.N.D. ; , 622; residents may pursue negligence claims, 742 NORWAY Mercury, brain damage in dental workers reported in Norwegian study, 218 NOTICE Asbestos. See ASBESTOS Indemnification --Late notice of superfund claim does not relieve excess insurer of liability D. Mass. ; , 142 --Settlement without notice to buyer, absent prejudice, did not violate pact D.N.J. ; , 586 Motor vehicles, new chemical use without notice, Infineum USA settles TSCA charges, 145 Pollution exclusion clause triggered by notice of liability letter D. Neb. ; , 669 RCRA --Citizen's suits, notice requirement applies to original, not amended, complaint D. Haw. ; , 587 --Hybrid complaints need not comply with notice and delay terms E.D. Mo. ; , 124 --Notice and delay terms for citizens' suits cannot be waived by private pact D. Utah ; , 123 NUCLEAR INDUSTRY See RADIATION NUISANCE Chemical pollution, mass tort suit remanded under Class Action Fairness Act 11th Cir. ; , 428 Lead paint. See LEAD PAINT Paper mill discharges, waterfront landowners denied class certification Fla. Cir. Ct. ; , 640 Tobacco, secondhand smoke, nuisance suit against neighbor denied Alaska ; , 639 O OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION OSHA ; Asbestos, courthouse exposure, negligence suit may proceed Mass. ; , 29 Beryllium and other chemicals, former OSHA official allowed exposure sampling records D.N.J. ; , 605 Health care workers, use of blunt-tip needles urged to decrease injuries, 392 Lead, scientists urge lowering OSHA standard, 31 Oversight measures expected to increase with Democratic win in Congress, 76 Pesticides, job pact mandating arbitration for tort claims upheld 3d Cir. ; , 560 Silicosis, workers' state claims not barred W. Va. ; , 5 and escitalopram, because dramamine pregnant.

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DURATION OF HUMAN MU OPIATE RECEPTOR BLOCKADE FOLLOWING NALTREXONE: MEASUREMENT BY 11CCARFENTANIL PET. E. M. Bednarczyk, PharmD, D. Wack, MS, M. Haka, PhD, Y. Shang, PhD, L. Hershey, MD, PhD, R. O'Sullivan, MD, T. Fullerton, PharmD, University at Buffalo, Pfizer, Buffalo, NY. BACKGROUND: Naltrexone is a mu opiate receptor antagonist approved for the treatment of alcohol dependency. Previous reports have suggested a duration of receptor occupancy of naltrexone that greatly exceeds that predicted by it's 4 hour T1 2, or the 13 hour T1 2 of beta naltrexol, the predominant metabolite. We undertook a double blind, placebo controlled, randomized study of receptor occupancy using the highly selective mu opiate receptor ligand 11C-carfentanil. METHODS: Healthy volunteers underwent PET imaging with 11C-carfentanil at baseline, 3 24, 72 and 144 hours following a single dose of placebo, 12.5, 50 or 100mg of naltrexone. Regional analysis was undertaken using a statistical parametric mapping approach SPM2 ; . RESULTS: To date, 15 of 24 subjects have completed all phases of the study. At interim analysis, regions of significantly p 0.001 ; lower activity were mapped in all known regions of brain mu and estrace.
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