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Alliances continued to proliferate through the early 2000s. Some equities analysts suggested consolidation might ensue in biotech, which dominated the pharmaceutical industry in the late 1990's and early 2000's, but the creation of new firms has far outstripped any consolidation Goldman Sachs, 2000 ; . The diversity of research and technology platforms encourages the use of alliances as a preferred mechanism over internal development. A very good example in this regard is the Roche Holding which uses partnering and and licensing to strengthen its overall product porfolio around a defined set of its perceived core competencies Cullen, 2004 ; . Even the largest and best financed pharma companies cannot afford to pursue all, or even most, emerging technology platforms through in-house R&D. Moreover, large pharma cannot afford to be left out, in the event that an emerging technology proves to be a major marketplace winner. A single technology platform may be able to turn out numerous drugs over a period of years. These new drugs could potentially be used to treat diseases in competition with a firm's existing products. Even a large pharma firm can require many years to recover from the loss of a major drug. Bringing a new drug to market requires upwards of 10 15 years from concept to revenue. Even after a new therapeutic enters clinical trials, the likelihood of the drug reaching the market remains low. As a consequence, the success of big pharma firms requires a deep and diverse pipeline of new drugs, Most of them plan to achieve this through mergers with some questionable results to date Raghavan and Naik, 2004 ; The renewed consolidation of the pharma industry during the 1990s and early 2000s has occurred to a great extent as a result of the need to expand drug development pipelines Filling the pipeline through acquisitions of other pharmaceutical or biotech firms has not been enough, even as many merged firms have been seeing their pipelines become even drier , prompting a leading Economist article claiming `Big Pharma needs a new Business Model' Economist, 2004 a, b ; . In fact, the acquisition of biotech firms by large pharma companies tends not to be very effective. As Robbins-Roth 2000 ; explored in his book acquisitions of biotech companies by large pharmaceutical firms just don't work. He cited the substantial differences in culture and approaches to R&D between large firms and their smaller counterparts that impede the innovative advantages of smaller firms. An exception may be Genentech, acquired by Roche in 28!
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