1. Cote CJ. Sedation for the pediatric patient: a review. Pediatr Clin North Am. 1994; 41: 31-58. Committee on Drugs. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics. 1992; 89: 1110-1115. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 1996; 84: 459-471. Pena BM, Krauss B. Adverse events of procedural sedation and analgesia in a ~ pediatric emergency department. Ann Emerg Med. 1999; 34: 483-491. Abeles G, Warmuth IP, Sequeira M, Swensen RD, Bisaccia E, Scarborough DA. The use of conscious sedation for outpatient dermatologic surgical procedures. Dermatol Surg. 2000; 26: 121-126.
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Male and female rats at doses of up to approximately 100 mg kg day ; . The NTP, however, found equivocal evidence for hepatocarcinogenicity in male mice. Hydrochlorothazide was not genotoxic In Vitro in the Ames mutagenicity assay of Salmonella Typhimurium strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 and in the Chinese Hamster Ovary CHO ; test for chromosomal aberrations, or In Vivo in assays using mouse germinal cell chromosomes, Chinese hamster bone marrow chromosomes, and the Drosophila sex-linked recessive lethal trait gene. Positive test results were obtained only in the In Vitro CHO Sister Chromatid Exchange clastogenicity ; and in the Mouse Lymphoma Cell mutagenicity ; assays, using concentrations of hydrochlorothiazide from 43 to 1300 mcgm mL, and in the Aspergillus Nidulans non-disjunction assay at an unspecified concentration. Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg kg, respectively, prior to mating and throughout gestation and hyzaar.
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USES: This medication is used to treat high blood pressure hypertension ; . Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is a combination of two drugs. Candesartan works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide increases the amount of urine you make, removing extra water and salt from your body. Candesartan belongs to a class of drugs called angiotensin receptor blockers, and hydrochlorothiazide is commonly called a "water pill" or diuretic. HOW TO USE: Take this medication by mouth, usually once daily or as directed by your doctor. You may take this drug with or without food. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. It is best to take this medication early in the day, before 4 p.m. to 6 p.m., to prevent having to wake up during the night to urinate. Consult your doctor or pharmacist if you have questions about your dosing schedule. Drink adequate fluids to prevent the loss of too much body water dehydration ; . If you are on restricted fluid intake, consult your doctor for further instructions. Do not take potassium supplements or salt substitutes containing potassium without talking to your doctor or pharmacist first. This medicine can infrequently raise or lower your potassium blood levels, which can rarely cause serious side effects such as muscle weakness cramping or fast slow irregular heartbeat. Tell your doctor immediately if any of these effects occur. The dosage is based on your medical condition and response to therapy. For the treatment of high blood pressure, it may take 4 weeks before you get the full benefit of this drug. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Cholestyramine and colestipol can decrease the absorption of hydrochlorothiazide. If you are taking either of these drugs, separate candesartan hydrochlorothiazide from cholestyramine by at least 4 hours and from colestipol by at least 2 hours. Inform your doctor if your condition worsens e.g., your routine blood pressure readings increase ; . MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. STORAGE: Store at room temperature at 77 degrees F 25 degrees C ; away from light and moisture. Brief storage between 59-86 degrees F 15-30 degrees C ; is permitted. Do not store in the bathroom. Keep all medicines away from children and pets. SIDE EFFECTS: See also How to Use section. You may experience dizziness, lightheadedness, and blurred vision as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of loss of too much body water and minerals e.g., unusual thirst, muscle cramps, weakness, confusion, fast irregular heartbeat, fainting, seizures ; , decreased sexual ability. Tell your doctor immediately if any of these rare but very serious side effects occur: unusual change in the amount of urine not including the normal increase in urine when you first start this drug ; , stomach abdominal pain, persistent nausea vomiting, yellowing eyes or skin, dark urine, unusual tiredness, muscle pain. 1 and ketamine.
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Depressed. Since the questions do not directly ask about mental health, the malaise score is likely to be less biased by stigma and misreporting than other, more direct measures. In fact, the malaise score tends to over-predict clinical depression Meltzer et al., 1995 ; , but is well correlated with diagnoses from clinical interviews Stansfeld and Marmot, 1992 ; or contact with mental health services Lindelow et al., 1997 ; . Annex 1 reports the answers to each component of the malaise score for the three adult waves. The most common predicament is to admit to "often worry about things" with at least a third of individuals giving this answer. The evolution of malaise score and depression over time is plotted respectively in Figure 1A and 1B. Malaise scores are skewed with a large proportion of individuals having a score of 0 and a fine tail of individuals with high score. The most noticeable pattern is that by age 42, the distribution becomes less skewed with a drop in the 0-frequency of 15 points and a fatter tail such that the probability of depression doubles and triples for women and men respectively; at each age, men are about 4 percentage points less depressed than women. This increase could be consistent with a reduction in the stigma associated with depression in the last decade. However, since we do not rely on a self assessment of depression and there is no change in the measurement of the score, the increase in score is likely be a mixture of age and a time effects6. For individuals in their forties the average malaise score increases by a full point. The main factors responsible for the increase in the scores are: feeling tired + 78 per cent ; , feeling miserable + 76 per cent ; , difficulty sleeping + 81 per cent ; , wake up early + 90 per cent ; and worry about health + 137 per cent ; . Additionally, the probability of having had a previous breakdown increases threefold between the twenties and forties. These statistics are broadly in line with the psychiatric and morbidity survey Singleton et al., 2001 and lanoxin!
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Welcome to IN Life Sciences, the e-newsletter of BioCrossroads formerly the Central Indiana Life Sciences Initiative ; - working to support basic sciences, attract new business and research opportunities and create more entrepreneurial capacity in the region in order to accelerate job creation in Central Indiana. : biocrossroads Dates to Remember: Professional Convention Management Association 48th Annual Meeting, January 11-14, 2004 Under the leadership of the Indianapolis Convention & Visitors Association, Indianapolis is rolling out the red carpet for the attendees with the newly-formed Bio Brigade, which is a diverse team of scientists, engineers, researchers, clinicians and other professionals that are informed and trained on the opportunities, resources, attractions and employment that exist in Central Indiana. This gathering will provide Central Indiana with a tremendous opportunity to sell its assets to the planners that make meeting destination decisions. You can visit ICVA's site, : indy , to access city, meeting venue, hotel and other destination information. Indiana Venture Center presentation in Anderson, January 13, 2004 The Flagship Enterprise Center will be hosting a luncheon to introduce the Indiana Venture Center to the Anderson area. If you are interested in attending, please contact Rory Small at rsmall indianaventurecenter Indiana Business Plan Forum, January 15, 2004 This bi-monthly series of seminars is designed to help Indiana's entrepreneurs develop solid, effective business plans tailored to potential investors and other valued stakeholders. This session's featured presenter is Matrix Global Partners. For more information about attending, go to : ventureclub Kelley School of Business - Indianapolis Health and Life Sciences Society Meeting, January 20, 2004 Deborah M. Green, Ph.D., Manager of Medical & Scientific Affairs for the U. S. Molecular Diagnostics division of Roche Diagnostics Corporation, will speak at the next Kelley School of Business - Indianapolis Health and Life Sciences Society meeting. Green plays a role in Roche's internal and external education programs pertaining to the disease states in the areas of HIV, HCV and Women's Health. Contact Ian Welsh for additional information on this event and the Health and Life Sciences Society at iwelsh HSRD.va.iupui . Statewide Incubator Manager's Conference, January 22, 2004 This event, hosted by the Indiana University Emerging Technologies Center, is a gathering of managers from university-affiliated business incubators from around the state for case studies, strategy, education and networking and lescol.
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