ACCOLATe . ACCUPRiL . See quinapril acetaminophen codeine acetazolamide . ACiPHeX . ACTiGALL . ursodiol ACTiveLLA . ACTONeL . ACTOS . ACULAR . acyclovir . ADALAT CC nifedipine eR ADDeRALL See amphetamine dextroamphetamine ADvAiR DiSKUS . albuterol inhaler . albuterol sulfate tabs, syrup . ALDACTONe . See spironolactone ALDOMeT . See see methyldopa ALLeGRA ALLeGRA-D . allopurinol . alprostadil . ALReX . ALTACe . amantadine . AMARYL . AMBieN . AMiCAR . See aminocaproic aminocaproic acid . amiodarone . amitriptyline . amoxicillin . amoxicillin clavulanate . amphetamine dextroamphetamine . ampicillin . ANAPROX . See naproxen sodium ANDRODeRM . ANDROXY . ANTABUSe . ANTARA anthralin.
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The next question for industry to answer is more complex: What are the effects of using cardiovascular and diabetes drugs to prevent or treat heart disease and diabetes? Several clinical trials are already underway to answer that. Three of the most prominent are: DREAM. In November 2000, GSK and Aventis announced the Diabetes Reduction Approaches with Ramipril Alrace ; and Rosiglitazone Avandia ; Medications DREAM.
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And lives and things into them, so I understand how you can become attached to a system. But for a smoker, what's the advantage of a $3 million system versus putting a red tab on the patient's file in the cabinet that says, "This is a smoker?" DR. NORRIS: The advantage is twofold. One, instead of looking to subset of our-- When you walk into the office, your physician is not just-When they see a dot on a chart, that's a dot on a chart. Then I have to go through each and every one of the visits, or I have to find a particular sheet on that particular issue, which literally I'm digging through paper instead of staring at you and talking to you. So, when a physician is in a room with a patient, this system brings that information to him very expeditiously in a systematic way. DR. METTLEN: Well, we found previously when we had the dot on the chart or the note in it -- in the paper world very rarely, probably less than 10 percent, did the physician ever discuss smoking cessation with patients. Now we know it's over 90 percent. Now we are just at the point where we are establishing base lines for all of these, because just coming from the paper world we really didn't know. We never knew how many physicians counseled patients, for instance, to quit smoking. Now we know and we're working on using those as targets to improve. In our OB GYN practices, for instance, the chair in meeting weekly with the faculty has the top 10 procedures that they believe are important, and they give each physician a rating on the percentages of patients that were offered those treatments or were screened. This is moving toward the 100 percent goal. What we know is that we started out with, in some cases, 14.
World" support groups. Most people are shy about joining a support group but don't be. You will be amazed at how quickly you feel at ease because the members know and understand what you are going through something hopefully ; nobody else in your circle of friends know about. A word of caution: support groups both online and "real world" ; play an important and in many cases, vital ; role in maintaining a positive outlook during treatment, as well as staying up to date on the latest brain tumor issues. However, you have to be cautious and evaluate how much you can trust anything you find. There are bad people out there looking to make money off of your misfortune, and even people who are trying to help might inadvertently supply you with misleading information. NOTHING on the internet or a support group meeting can be taken as medical advice. You have to research anything you find and discuss it with your doctors. The chat rooms are most susceptible to problems because there may not be other people to discuss the pros and cons of the treatment. On the other hand, in an online support group like the brain-temozolomide list, you can ask for many people's experiences with a treatment and get a broader view of it. The Brain Tumor Virtual Trial This is a study being run by the Musella Foundation. It is a database of brain tumor patients, the treatments they are using and the outcomes. Participants record the treatments that they and their doctors decide to pursue we do not tell you what treatments to do we just record the outcome ; . There is no cost to participate. The patient or caregiver records information in simple forms on our website, and posts an update every month. We send email reminders on the first of every month. You also send in a copy of each of your MRI reports and pathology reports not the films ; so that we can verify the information. Participants get to view the ongoing results of the project. The idea is to try to identify which treatments or combination of treatments - are working the best. In addition to providing greater insight to beneficial therapies for researchers, participants become expert managers of their condition, and can generate reports on the information they entered such as a graph of their status over time. To join, or for more information, go to: : virtualtrials brain Mind, Body & Soul While your primary physician may appear anything but spiritual in his her approach to your brain tumor, many within the medical community are aware, and in support of, the power of prayer. Prayer, while very personal, can be empowering and pro-active at times when "control" seems out of reach. To add your name to the Musella Foundation prayer list, visit: : virtualtrials prayer and amaryl.
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Case western reserve university, cleveland, oh; statistical & data analysis ctr, harvard school of public health, boston, ma; university of pennsylvania, philadelphia, pa; university of nebraska medical ctr, omaha, ne; social & sci systems, silver spring, md; niaid, nih, bethesda, md; frontier sci & tech research fndn, amherst, ny; brown medical school, providence, ri; university of california, san diego, ca; university of north carolina at chapel hill, nc.
Products. As a result of this process, we necessarily incurred significant charges for special items during 2004." Information regarding special items is provided below. "In addition, we have made other important strides that significantly contribute toward our goal of reestablishing a firm foundation on which to build the Company's future success, " added Mr. Markison. "These other significant accomplishments include relocating our commercial operations organization to New Jersey, expanding our business development group, reprioritizing our research and development portfolio, right-sizing our sales force, and implementing new processes and policies to enhance financial controls, institutionalize cost control and improve production planning." Mr. Markison emphasized, "While taking these actions to financially rebase the Company, it is important to note that we continued to generate strong cash flow. Although King's total revenues decreased 13% in 2004, cash and cash equivalents, not including restricted cash, grew to $342.1 million as of December 31, 2004, an increase of 134% from $146.1 million at the end of 2003." In conclusion, Mr. Markison said, "With our significantly enhanced commercial operations capability, we plan to maximize the potential of the Company's currently marketed products as a revenue-generating platform to fund product development and business development. By adding strategic assets, developing new partnerships, and divesting underperforming assets, we expect to improve the Company's long-term prospects and build value for our shareholders. With our excellent cash flow, strong balance sheet and enhanced core capabilities, we believe that we have turned the Company in the right direction and are poised for growth in 2005." The Company intends to host a conference call and webcast on Tuesday, April 12, 2005 to present and discuss the Company's strategic plan for renewed growth and future expectations. Conference call and webcast information will be provided when available via a subsequent press release. The decreases in King's revenues during the fourth quarter and the twelve months ending December 31, 2004 in comparison to the same periods of the prior year are attributable primarily to aggressive wholesale inventory reductions of the Company's branded pharmaceutical products. These reductions are due to the Company's implementation of wholesale inventory management agreements in early 2004. Based on the Company's belief that these reductions will not be substantially complete until the end of the first quarter of 2005, the Company anticipates that its net sales in the current quarter could be similar to its results in the fourth quarter of 2004. Net revenue from branded pharmaceuticals, including royalty income, totaled $308.0 million for the fourth quarter of 2004, a 7% decrease from the fourth quarter of 2003, and equaled $1.15 billion for the year ending December 31, 2004, a 14% decrease from the prior year. Meridian, King's wholly-owned subsidiary, contributed $27.2 million to the Company's net revenue in the fourth quarter of 2004 and $123.3 million during the year ending December 31, 2004. During the fourth quarter and year ending December 31, 2004, net revenue from contract manufacturing and other equaled $7.5 million and $26.0 million, respectively. Altave net sales equaled $91.7 million in the fourth quarter of 2004, compared to $116.4 million during the fourth quarter of 2003. As of year-end 2004, the Company estimates that wholesale inventory levels of Al6ace equaled approximately 1.7 months of end-user demand. Although the Company anticipates some continued wholesale inventory reductions of Atace during the first quarter of 2005 at a level similar to that observed during the fourth quarter of 2004, it believes that net sales of this product during the following three quarters of 2005 should more closely reflect demand-based sales and amitriptyline.
PHARMAC's use of reference pricing differs significantly from that used in other countries, by including patented products in therapeutic reference groups with generic products. This policy erodes the value of intellectual property accrued through innovation.
MOL 35535 Table I and Fig. 3G ; . However, TAK-013 only displays insurmountable properties at the macaque receptor similar to the hGnRHR when the combined P203S and V300L mutations are present Table I and Fig. 3H ; . Mutational analysis of the 2nd and 3rd extracellular loops of the human GnRHR To further map the interactions responsible for tight binding and insurmountable antagonism of TAK-013, Ser-203 and Leu-300 were mutated to a variety residues with nonpolar, polar, and charged side chains Table II ; and expressed transiently in HEK293 cells. When Ser-203 is changed to a nonpolar residue, alanine, or to uncharged polar residues, threonine and asparagine, TAK-013 retains its insurmountable property at the receptor. However, when Ser-203 is mutated to aspartic acid or glutamic acid, both charged residues, the insurmountability is disrupted, as it is with the inclusion of proline at this position. These results show that position 203 is permissive for the conformation necessary for insurmountability, since only a large disruption of the structure by proline or insertion of a charge alters TAK-013 insurmountable antagonism. The valine at position 300 in the macaque receptor is structurally similar to the leucine found in the human receptor, yet this small change is sufficient for the complete loss of insurmountability, as shown in Tables I and II and Fig 3C. A more conservative change is to the -branched isoleucine instead of the -branched leucine at residue 300, yet, this mutant also caused TAK-013 to become surmountable. Further mutations of Leu-300 included changes to an alanine and to a threonine, both of which resulted in a loss of insurmountability Table II ; . These results indicate that a leucine at 300 is critical to maintain the insurmountability of TAK013 since even the smallest change in side chain structure from -branched to -branched residues ; ablates this property and amoxicillin.
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Do not use this medication if you are allergic to altac3 or to any other ace inhibitor, such as benazopril lotensin ; , captopril capoten ; , fosinopril monopril ; , enalapril vasotec ; , lisinopril prinivil, zestril ; , moexipril univasc ; , perindopril aceon ; , quinapril accupril ; , or trandolapril mavik and amoxil.
Allopurinol, Cont. ; 5 Probenecid, 23 5 Quinethazone, 24 4 Theophylline, 1177 4 Theophyllines, 1177 5 Thiazide Diuretics, 24 1 Thiopurines, 1229 5 Trichlormethiazide, 24 4 Warfarin, 64 Alprazolam, 3 Aminophylline, 207 4 Atracurium, 891 2 Azole Antifungal Agents, 178 4 Carbamazepine, 180 2 Clarithromycin, 196 3 Cimetidine, 182 3 Contraceptives, Oral, 186 2 Delavirdine, 198 4 Digoxin, 471 3 Disulfiram, 189 5 Divalproex Sodium, 208 3 Dyphylline, 207 2 Efavirenz, 198 2 Erythromycin, 196 2 Ethanol, 546 4 Ethotoin, 647 2 Fluconazole, 178 5 Fluoxetine, 190 3 Fluvoxamine, 191 4 Fosphenytoin, 647 4 Gallamine Triethiodide, 891 4 Hydantoins, 647 2 Indinavir, 193 5 Isoniazid, 194 2 Itraconazole, 178 2 Ketoconazole, 178 5 Levodopa, 737 2 Macrolide Antibiotics, 196 4 Mephenytoin, 647 4 Metocurine Iodide, 891 2 Miconazole, 178 3 Nefazodone, 197 2 NNRT Inhibitors, 198 4 Nondepolarizing Muscle Relaxants, 891 3 Omeprazole, 199 3 Oxtriphylline, 207 4 Pancuronium, 891 4 Phenytoin, 647 5 Propoxyphene, 202 3 Rifabutin, 205 3 Rifampin, 205 3 Rifamycins, 205 2 Rifapentine, 205 2 Ritonavir, 206 3 Theophylline, 207 3 Theophyllines, 207 2 Troleandomycin, 196 4 Tubocurarine, 891 5 Valproic Acid, 208 4 Vecuronium, 891 Alseroxylon, 2 Dobutamine, 1141 2 Dopamine, 1141 2 Ephedrine, 1141 2 Epinephrine, 1141 4 General Anesthetics, 1032 2 Mephentermine, 1141 2 Metaraminol, 1141 2 Methoxamine, 1141 2 Norepinephrine, 1141 2 Phenylephrine, 1141 2 Sympathomimetics, 1141 Altace, see Ramipril Alteplase, 1 Nitroglycerin, 25 AlternaGEL, see Aluminum Hydroxide.
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Regarding allergic conjunctivitis in children: "The single best morsel of advice I can give to the parents of an allergic child is to wash their child's hands frequently. Children just won't stop rubbing their itchy eyes, " Dr. Sheppard says.7 "So many of the oral anti-allergy drugs have significant drying effect on the eye. That just creates more problems in addition to the frequent behavioral changes seen in children taking antihistamines orally, " he says. If a topical antihistamine mast cell stabilizer such as Patanol fails to achieve relief, then certainly try a pulse dose course of Lotemax every two hours for four days; then use both Patanol and Lotemax b.i.d. for a week. At the end of this short pulse of corticosteroid, the condition should be sufficiently con and atenolol.
Futrell N: Inflammatory Vascular Disorders: Diagnosis and Treatment in Ischemic Strokes; Current Opinions in Neurology. 8: 55, Feb, 1995. 10. Kato H, Shrahama M, Ohmori K: Cerebral Infarction in A Young Adult Associated with Protein C Deficiency. Angiology.46: i 69, Feb, ] 995 11. Rick M: Protein CCoagulation. S- Vitamin American MeInhibitors of Blood and Protein Journal of K Dependent dical Association.263: 701, Feb 1990. 12. Koller H, Stall 3: Deficiency of both Protein C and S in a Family with Ischemic Strokes in Young Adults. Neurology. 1238. July 1994. 13. Fauci A: Braunwald E: Harrison's Principleof Internal Medicine. 14th Edition 1: 736, 1998.
Previous Cannabis users, showed minimum physiological responses, but suffered impaired intellectual functioning and decreased body steadiness, especially well demonstrated by non-users after high doses. Basic personality structures remained unchanged as subjects reported feelings of relaxation, disinhibition, and self-confidence. In that study, the drug was administered orally as an extract. No controls were described, and doses and quality of marijuana were unspecified. Williams et al. in 1946' studied a small number of prisoners who were chronic users; they were chiefly interested in effects of long-term smoking on psychological functioning. They found an initial exhilaration and euphoria which gave way after a few days of smoking to indifference and lassitude that somewhat impaired performance requiring concentration and manual dexterity. Again, no controls were provided. Predictably, these studies, each deficient in design for obtaining reliable physiological and psychological data, contributed no dramatic or conclusive results. The 1967 President's Commission on Law Enforcement and the Administration of Justice described the present state of knowledge by concluding: 3 " careful and detailed analysis of the American experience [with marijuana] seems to have been attempted. Basic research has been almost nonexistent " Since then, no other studies with marijuana itself have been reported, but in 1967 Isbell' administered synthetic THC to chronic users. At doses of 120 pglkg orally or 50 pglkg by smoking, subjects reported this drug to be similar to marijuana. At higher doses 300 to 400 pg kg orally or 200 to 250 pg kg by smoking ; , psychotomimetic effects occurred in most subjects. This synthetic has not yet been compared with marijuana in non-users or given to any subjects along with marijuana in double-blind fashion. Investigations outside the United States have been scientifically deficient, and for the most part have been limited to anecdotal and sociological approaches.`-` * So far as we know, our study is the first attempt to investigate marijuana in a formal double-blind experiment with the appropriate controls. It is also the first attempt to collect basic clinical and psychological information on the drug by observing its effects on marijuana-naive human subjects in a neutral laboratory setting and atrovent and altace, for instance, altace forum.
The market value of the Novartis AG shares held by the foundation at December 31, 2002 was CHF 4.8 billion 2001: CHF 6.1 billion ; . 27. Related parties The Novartis Group has formed certain foundations with the purposes of advancing employee welfare, employee share participation, research and charitable contributions. The charitable foundations foster health care and social development in rural countries. The foundations are autonomous, and their boards are responsible for administering the foundations in accordance with the foundations' purpose and applicable law. The employee share participation foundation has not been included in the consolidated financial statements prepared under IAS as Interpretation No. 12 of the IAS Standing Interpretations Committee exempts post-employment and equity compensation plans from its scope. The total assets of this foundation as of December 31, 2002 included 95.1 million shares of Novartis AG with a market value of CHF 4.8 billion. As of December 31, 2001, the assets included 101.3 million Novartis shares with a market value of CHF 6.1 billion. This foundation is consolidated under US GAAP and is included as a reconciling item in the US GAAP reconciliation. In 2002, the Group granted short-term loans totaling CHF 875 million to the above mentioned foundations and received short-term loans totaling CHF 3 million from them. In 2001, the Group granted short-term loans totaling CHF 1, 189 million to the foundations, received short-term loans totaling CHF 10 million from them. In 2000, the Group granted short-term loans totaling CHF 936 million to the foundations, received short-term loans totaling CHF 6 million from them and sold 1.4 million Novartis shares to them at market prices. In addition, there are approximately twenty other foundations that were established for charitable purposes that have not been consolidated, as the Group does not receive a benefit therefrom. As of December 31, 2002 these foundations held approximately 6.1 million shares of Novartis 2001: 6.2 million shares ; , with a cost of approximately CHF 39 million 2001: CHF 39 million ; . See notes 5, 25 and 26 to the consolidated financial statements for disclosure of other related party transactions and balances.
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BAKER AR, MCDONNELL DP, HUGHES M et al.: Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 85, 3294-3298, 1988 BAUDINO TA, KRAICHELY DM, JE.COAT SC, Jr et al.: Isolation and characterization of a novel coactivator protein, NCoA62, involved in vitamin D-mediated transcription. J Biol Chem 273, 16434-16441, 1998 BHATTACHARJEE M, WIENTROUB S, VONDERHAAR BK: Milk protein synthesis by mammary glands of vitamin D-deficient mice. Endocrinology 121, 865-874, 1987 BIKLE DD, PILLAI S: Vitamin D, calcium, and epidermal differentiation. Endocr Rev 14, 3-19, 1993 BRTKO J, THALHAMER J: Renaissance of the biologically active vitamin a derivatives: established and novel directed therapies for cancer and chemoprevention. Curr Pharm Des 9, 2067-2077, 2003 CARLBERG C: Molecular basis of the selective activity of vitamin D analogues. J Cell Biochem 88, 274-281, 2003 CHEN H, LIN RJ, SCHILTZ RL et al.: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P CA. and CBP p300. Cell 90, 569-580, 1997 CHOI M, YAMAMOTO K, ITOH T et al.: Interaction between vitamin D receptor and vitamin D ligands. Two-dimensional alanine scanning mutational analysis. Chem Biol 10, 261-270, 2003 CHRISTAKOS S, RAVAL-PANDYA M, WERNYJ RP et al.: Genomic mechanisms involved in the pleiotropic actions of 1, 25dihydroxyvitamin D3. Biochem J 316, 361-371, 1996 CLEMENS TL, ADAMS JS, HENDERSON SL et al.: Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet 1, 74-76, 1982 CORDER EH, GUESS HA, HULKA BS et al.: Vitamin D and prostate cancer: a prediagnostic study with stored sera. Cancer Epidemiol Biomarkers Prev 2, 467-472, 1993 CROSS HS, PETERLIK M, REDDY GS et al.: Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J Steroid Biochem Mol Biol 62, 21-28, 1997 DARWISH H, DELUCA H.: Vitamin D-regulated gene expression. Crit Rev Eukaryot Gene Expr 3, 89-116, 1993 DARWISH HM, DELUCA H.: Recent advances in the molecular biology of vitamin D action. Prog Nucleic Acid Res Mol Biol 53, 321-344, 1996.
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Name of pharmaceutical product and, if applicable, the dosage form, strength and route of administration ; for export to name of country or WTO Member ; 1. I hereby authorize to make, construct and use, the patented invention s ; identified in patent number s ; solely for purposes directly related to the manufacture of the above-mentioned pharmaceutical product, and to sell it for export to the above-mentioned country or WTO Member 2. The quantity of the pharmaceutical product authorized to be manufactured by this authorization is 3. In accordance with section 21.09 of the Act, this authorization is valid for a period of two years beginning on the date shown below. Granted at the day of , name of applicant ; , whose postal address is, for example, altace cap.
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