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Lawrence F. Galvin [Judges: Bryson author ; , Newman, and Archer] In Asyst Technologies, Inc. v. Empak, Inc., No. 00-1514 Fed. Cir. Oct. 10, 2001 ; , the Federal Circuit reversed and remanded a district court's decision granting SJ of noninfringement of the asserted claims. The processing of semiconductor wafers into integrated circuits must occur in an ultraclean environment, such as a sealed transportable container, to avoid manufacturing defects. The complexity and minute dimensions involved in this processing require computer monitoring and verification systems to ensure the quality of the resulting integrated circuits. Asyst Technologies, Inc. "Asyst" ; owns U.S. Patent Nos. 4, 974, 166 "the `166 patent" ; and.
A new treatment paradigm for early type 2 diabetes, described in the May issue of Diabetes Care, involves inhibition of dipeptidyl peptidase IV DPP IV ; . "This study provides the first evidence that pharmacological DPP IV inhibition is feasible for the treatment of type 2 diabetes in humans", "write Bo Ahren, MD, from Lund University in Malmo, Sweden, and colleagues. Although glucagon-like peptide-1 GLP-1 ; has potential for treatment of type 2 diabetes, its short halflife prompted investigation of inhibitors of the GLP-1degrading enzyme DPP IV, which improve glucose tolerance in insulin-resistant rats and mice. This double-blind, multicenter trial involved the selective, orally active DPP IV inhibitor NVP DPP 728. Over the 4-week treatment period, 61 men and 32 women with diet-controlled type 2 diabetes mean age, 64 years ; received placebo or the inhibitor at a dose of 100 mg three times daily or 150 mg twice daily. There were no significant adverse effects. Compared with placebo, NVP DPP728 at 100 mg three times daily reduced mean fasting glucose by 1.0 mmol L, prandial glucose excursions by 1.2 mmol L, and mean 24-hour glucose levels by 1.0 mmol l all P .001 ; . Reductions were similar in subjects receiving 150 mg twice daily, and mean 24-hour insulin levels were reduced by 26 pmol L in both active treatment groups. An unexpected benefit was that HbA1c in the combined active treatment groups decreased by 0.6% P .001 ; . "There was no difference between a three-times-daily treatment schedule versus a twice-daily treatment schedule with NVP DPP728, indicating that either dosing regimen could probably be used with equal efficacy", the authors write. "Further long-term studies will be needed to examine the long-term effects of DPP IV inhibition as well as to fully understand the mechanism of the effects and to define the use of this approach in patients with more advanced diabetes and in combination with other antidiabetic drugs." Diabetes Care. 2002; 25 5 ; : 869-875 TRIAL OF ARTFICIAL PANCREAS SET FOR LAUNCH Clinical trials will begin next month for a prototype artificial pancreas that should enable patients with type 1 diabetes to have more controlled levels of blood glucose with fewer episodes of hypoglycemia than are, for example, cardura e10.
Background: We recently published preliminary evidence on the effectiveness of hypertonic saline in infants with viral bronc c chiolitis. Objective: To further establish the efficacy of nebulized hypert c tonic saline in these infants Methods: In a continuing, secondtyear randomized, doublet blind controlled trial, an additional 41 infants age 2.6 1 months ; hospitalized with viral bronchiolitis were recruited during the winter of 20012002. The infants received inhalation of 1.5 mg epinephc c rine dissolved either in 4 ml normal 0.9% ; saline Group I, n 20 ; or hypertonic 3% ; saline Group II, n 22 ; . The therapy was repeated three times daily until discharge. Pooling our 2 years of experience 20002002 ; , a total of 93 hospitalized infants with viral bronchiolitis were recruited; 45 were assigned to Group I and 48 to Group II. Results: The clinical scores at baseline were 7.6 0.7 for Group I vs. 7.4 1.3 for Group II P NS ; However, the clinical scores at days 1 and 2 after inhalation differed significantly between the two groups, invariably favoring Group II: 7 1 vs. 6.25 1.1 P 0.05 ; , 6.45 1 vs. 5.35 1.35 P 0.05 ; , respectively. Adding aerosolized 3% saline to 1.5 mg epinephrine reduced the hospitalization stay from 3.5 1.7 days in Group I to 2.6 1.4 in Group II P 0.05 ; . The pooled data of both years revealed that adding 3% saline to the inhalation mixture decreased hospitalization stay from 3.6 1.6 to 2.8 1.3 days P 0.05 ; . Conclusions: This secondcyear experience and our 2 year pooled data analysis strengthen the evidence that the combination of 3% saline 1.5 mg epinephrine benefits hospitalized infants with viral bronchiolitis.
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Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Received for publication: October 25, 2001. Reprint request: Usa Thisyakorn, M.D., Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Keywords: Dengue virus, dengue fever, dengue hemorrhagic fever, dengue shock syndrome, DF, DHF, DSS and carisoprodol.
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On September 2, 2004, the Center for Disease Control reported that in 2001, more than 157, 000 Americans were killed and about 29.7 million injured as a result of car accidents, falls, violent acts and other accidents. In its first of a kind study, the CDC reported that across the 50 states and the District of Columbia, unintentional injuries are the fifth leading cause of death after heart disease, cancer, stroke and lower respiratory illness. Teenagers and young adults between the ages of 15 and 24 had the highest risk of dying in a motor vehicle accident in 2001. Automobile accidents accounted for almost 33, 400 death and 2.9 million non-fatal injuries. Sadly, the CDC report also point out that 10, 000 more Americans died from committing suicide 31, 000 ; , than from homicides 21, 000 ; . The take home message is simple: accidents can and do happen. However, there are measures to take as to reduce your likelihood of being a statistic. Use common sense, slow down, and pay attention to what you are doing at that moment. If stressors in your life seem to be unmanageable, speak to someone about it. As the CDC report shows, for too many Americans, particularly young adult Americans, their lives are being cut short as a result of accidents that may be preventable. As both an athletic training professional and a apparent of two young adults, one of whom is a student-athlete at Syracuse University, this report confirms many of the concern I have daily on the safety and health of young adults, particularly our student-athletes. I know this concern is shared by all university and athletic department administrators, sports medicine staff, physicians, coaches and parents. Please be aware, and be safe, for example, carcura side effect.
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Problem 2: Patient is not clear about her role in her overall recovery Outcome: Patient will be able to use words to describe her mood that do not include diagnostic terms. date ; Outcome: Patient will be able to use feelings tracking sheets to identify the connection between mood states and cravings to: use drugs ETOH, purge, act out sexually date ; Outcome: Patient will report how the use of this tool helps her to identify her role in her overall recovery date ; Outcome: Patient will set appropriate limits with mother's involvement in treatment. date ; Staff Intervention: DBT Based intervention for affect dysregulation management. Introduce the concept of affect cravings; educate patient in the use of vocabulary words to describe her moods. Will provide education to mother boundaries and supports while evaluating the need for reporting this case to SRS.
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