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Matz, R. ve di. : Clozapine a potential antipsychotic agent without extrapyramidal manifestations. Curr. Ther. Res. 16: 687, 1974. McCreadie, R. C. ve di.: High dose flupenthixol decanoate in chronic schizophrenia. Brit. J. Psychiat. 135: 175, 1979. McCreadie, R. C. ve di.: Intermittent pimozide versus fluphenazine decanoate as maintenance therapy in chronic schizophrenia. Brit. J. Psychiat. 137: 510, 1988. McEvoy, J. P. : The clinical use of anticholinergic drugs as treatment for extrapyramidal side effects of neuroleptic drugs. J. Clin. Psychoparmacol. 3: 288, 1983. Missale, C. ve di.: Dopamine receptors: from structure to function. Physiol. Rev. 78: 189, 1998. Morris, P. A. ve di.: A comparative doubleblind trial of pimozide and fluphenazine in chronic schizophrenia. Brit. J. Psychiat. 117: 683, 1970. Moskowitz, C. ve H. L. Klawans: Theoretical aspects of the pharmacology of affective disorders. Clinical Neuropharmacology'de Ed.: H.L. Klawans ; , 2. Cilt, Raven, New York, 1976. Nestoros, J. N. ve H. Lehmann: Neuroleptics and male sexual dysfunction. Internat. Drug. Ther. Newslett., 14: 21, 1979. Nishiura, M. : Clinicopharmacological studies of sulpiride. Curr. Ther. Res. 20: 164, 1976. Owen, F. ve di. : Increased dopamine receptor sensitivity in schizophrenia. Lancet 2: 223, 1978. Perriss, C. ve di. : Tardive dyskinesia in psychiatric patients treated with neuroleptics. Brit. J. Psychiat. 122: 385, 1979. Pickar, D. ve di.: Clinical response to clozapine in patients with schizophrenia. Arch. Int. Psychiat. 51: 159, 1994. Pilowsky, L. S. ve di. : Clozapine, simple photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 340: 199, 1992. Post, R. M. ve di.: Dopamine and mania: behavioral an biochemical effects of the dopamine receptor blocker pimozide. Psychoparmacol. 67: 297, 1980. Potkin, S. G. : Phenylethylamine in paranoid chronic schizophrenia. Science 206: 470, 1979. Quitkin, F. ve di. : Long acting oral vs injectable antipsychotic drugs in schizophrenics. Arch. Gen Psychiat. 35: 889, 1978. Rupniak, N.M.J. ve di.: Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat. Psychopharmacol. 84: 503, 1984. Sedvall, G. Ed. ; : Melperonean atypical neuroleptic. Acta Psychiat. Scand. 80 Suppl. 352 ; , 1989 birok makale ; . Seeman, P.: Brain dopamine receptors. Pharmacol. Rev. 32: 229, 1980. Seeman, P. ve H.M. Van Tol: Dopamine receptor pharmacology. TIPS 15: 264, 1994. Seeman, P. ve di.: Dopamine D 4 receptors elevated in schizophrenia. Nature 365: 441, 1993. Sesack, S. R. ve B.S. Bunney: Central dopaminergic systems: Neurophysiology and electrophysiological pharmacology. Neurochemistry and Neuropharmacology of Schizophrenia'da Ed.: F. A. Henn ve L. E. DeLisi ; , s. 149, Elsevier, Amsterdam, 1967. Seth, S. ve di. : A double blind comparative trial of loxapine and trifluoperazine in chronic schizophrenic patients. Curr. Ther. Res. 25: 320, 1979. Shopsin, B. ve di. : Clozapine, chlorpromazine, and placebo in.

Uring the Annual Business Meeting of ASPI, March 18, 2005, in Key Biscayne, Fla., members elected the Class of 2008 to the Board of Directors. Three of the four members of the Class of 2008 are returning board members, previously in the Class of 2005. Marcus Pillion, director, John Crane Safematic Bearing Lubrication Division, was elected to the class of 2008 and is new to the Board of Directors. Pillion is responsible for the North American market. He has more than 10 years experience in the implementation and management of European based solutions into the North American market primarily focused in the pulp and paper market segment. Pillion has been involved in all facets of the business including sales, marketing, engineering, supply, installation and service. He is committed to fostering the development of a much-needed strategic alliance between local customer support channels, engineering, supplier, contractor and owner to successfully increase the reliability of North American mills and plants. The results increase the opportunity for North American mills and plants to be more competitive in the global marketplace. He holds a Bachelors degree from the College of Wooster. Returning members of the board in the Class of 2008 are: Rodney Fisher, president, Fisher International, Inc.; Ed Ryan, president, Sandusky International, Inc.; and Thomas E. Vaughn, vice president, sales & marketing, Kadant AES. ASPI welcomes Marcus Pillion to the board and appreciates the continued support of Rod Fisher, Edward Ryan and Tom Vaughn.

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Will improve the response to treatment. This outcome, however, does not necessarily result. A review of 6 double-blind clinical trials by Collins, Hogan, and Awad 66 ; revealed that in only one clinical trial was treatment with a higher dose superior to treatment with the standard dose. In 4 of the clinical trials, there was no difference in therapeutic effectiveness between the groups treated with high and with standard doses, and in one clinical trial, the group treated with a standard low ; dose actually fared better than the group treated with a high dose. On the basis of pharmacokinetic findings, Van Putten and others 67 ; maintain that, apart from demonstrably low plasma levels--as a result of poor absorption and or rapid drug metabolism--there is no known indication for an increase above the recommended dose of antipsychotics. In keeping with this conclusion are the results of a recent study that showed that doses as low as 2 to mg of haloperidol attained the dopamine D2 PET occupancy associated with therapeutic response 68 ; . Replacement of Oral with Depot Preparations Noncompliance is frequently the cause of apparent refractoriness to treatment. It is encountered in as high as 60% of schizophrenia outpatients within 6 weeks of starting treatment with an oral antipsychotic 69 ; . Considering that approximately two-thirds 67% ; of patients with schizophrenia relapse within a year if their antipsychotic medication is withheld 70 ; , noncompliance is one of the most common findings in patients who responded to treatment initially but whose responsiveness to the antipsychotic seemed to wear off after a certain period of time 71 ; . The primary approach to overcoming noncompliance is the replacement of the oral with a long-acting, depot preparation. It is an effective measure in preventing relapse that results from noncompliance. The survival rate of discharged patients in the community within a period of 24 months is significantly longer 72 ; , and the occurrence of relapse within a period of 30 months significantly lower in patients treated with a depot than with an oral antipsychotic. There are 8 antipsychotics with 11 depot preparations listed in the seventh edition of the Index Psychopharmacorum, published in 1990. Of these 11 preparations, 6 are available in Canada for clinical use: the piperidylalkyl pipothiazine palmitate, the piperazinylalkyls fluphenazine decanoate and enanthate, the butyrophenone haloperidol decanoate, and the thioxanthenes flupentthixol decanoate and flupenthkxol enanthate. Substitution of One Antipsychotic with Another Selection of the wrong medication for an individual patient is not infrequently the cause for apparent refractoriness to antipsychotics. This fact is remarkably understudied.
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Three reviews were meta-analyses 21-23 ; , while the other seven were qualitative systematic reviews. The New Zealand Health Technology Assessment NZHTA ; Agency published a series of reports Evidence tables ; on suicide preventive interventions see Appendix 3 ; . These NZHTA reports did not include a qualitative synthesis which was one of our inclusion criteria see Appendix 1 ; and thus these reports were not included in our review. The various types of suicide-preventive interventions evaluated in these systematic reviews are presented in Box 2 using the previously presented framework see Box 1 ; . About 30 suicide-preventive interventions were evaluated and more than half fall into the domain of treatment rather than prevention and maintenance. Box 2: Suicide preventive interventions identified in systematic reviews Prevention Universal media reporting responsibility restrictions 14, 15 ; means access restrictions 14, 15 ; Selective safety measures on high buildings 14 ; suicide prevention centres 14, 15 ; school-based suicide prevention programmes 14, 15, 16, ; Indicated educating general practitioners 14, 15 ; computer assisted help Internet ; 15 ; postvention 15, 18 ; Treatment Case identification screening 14 ; increased identification support 14 ; youth health clinics 15 ; Therapies Medical and non-medical treatments ; antidepressants 15, 19, 22 ; flupejthixol 19, 22 ; general hospital admission 19, 22 ; electroconvulsive therapy 14 ; intensive care plus outreach 19, 22 ; inpatient treatment 20 ; group support 15 ; cognitive behavioural therapy 15, 21 ; problem-solving 15, 19, 22 ; dialectical behaviour therapy 19, 22 ; inpatients behaviour therapy 19, 22 ; home-based family therapy 15, 19, 22 ; psychosocial crisis intervention 21. REPUBLIC OF GHANA Ministry of Health Ghana National Drugs Programme GNDP ; Fifth Edition, 2004 Ministry of Health GNDP ; Ghana All rights reserved. No part of this publication may be reproduced, stored in a retrival system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording and or otherwise, without prior written permission of the Ministry of Health, Ghana Essential Drugs List & National Formulary with Therapeutic Guidelines, 1st Edition, 1988 Essential Drugs List & National Formulary with Therapeutic Guidelines, 2nd Edition, 1993 Essential Drugs List & National Formulary with Therapeutic Guidelines, 3rd Edition, 1996 Ghana Essential Drugs List, 4th Edition, 2000 Ghana Essential Medicines List, 5th Edition, 2004 ISBN 9988-8283-2-2 For all enquiries write to the publishers: Ghana National Drugs Programme GNDP ; Ministry of Health P.O. Box MB-582, Accra, Ghana, West Africa Tel: + 233 0 ; 21 661 670 Fax: + 233 0 ; 21 664309 E-mail: gndp ighmail Website: moh-ghana Printed by Yamens Press Limited, Accra, Ghana, West Africa. Tel: + 233 0 ; 21 223 222 Materials Development Consultant: E.T.A. Abbey P.O. Box AN 5116 Accra, Ghana, West Africa Tel: + 233 0 ; 21 304 211 + 233 0 ; 21 313 843 and glipizide. Table 8. Course of pulmonary diseases and HIV infection in adults. Foot salvage techniques in dogs and cats: options, "do's" and "don'ts." Swaim SF, Garrett PD. JAAHA 21: 511-519, 1985. Paw and distal limb salvage and reconstructive techniques. Swaim SF, Scardino MS. In Bojrab MJ ed ; : Current Techniques in Small Animal Surgery, 4th ed--Philadelphia: Williams & Wilkins, 1998, pp 625-638. Reconstructive microsurgical applications. Fowler JD. In Bojrab MJ ed ; : Current Techniques in Small Animal Surgery, 4th ed-- Philadelphia: Williams & Wilkins, 1998, pp 607622. Use of the carpal pad to salvage the forelimb in a dog and cat: an alternative to total limb amputation. Barclay CG, Fowler JD, Basher AW. JAAHA 23: 527-532, 1987. THERAPEUTIC DIETS Louise S. Dunn & Nan Boss References 1. Principles of veterinary medical ethics. Glossary. 2004 AVMA Membership Directory and Resource Manual--Schaumburg, Illinois: American Veterinary Medical Association, 2004, pp 40-42. 2. Insides from the KPMG product profitability study. Wayner C. WVC Proc, 2003. 3. The Path to High-Quality Care: Practical Tips for Improving Compliance. AAHA 2002 Compliance Study report ; --Lakewood, CO: American Animal Hospital Association, 2003, p 82. Resources Educating Clients from A to Z: What to Say and How to Say It. Boss N--Lakewood, CO: AAHA Press, 1999. Six teams take charge of compliance. Gavzer K. Vet Econ, October 2004, pp 49-61. The role of nutrition in marketing. Mastering the Marketplace: Taking Your Practice to the Top. Clark R--Lenexa, KS: Veterinary Medicine Publishing Group, 1996. Veterinary Nutritional Advocate VNA free online training program from Hill's Pet Nutrition, 800-548-8387, vna.hillsvet ncvei . Click on the "Exam Room" tab and select: Will My Fees Keep Me Afloat, Where is My Money Coming From, What's My Bottom Line and grisactin. Only one analytic case-control study has described in detail the characteristics and risk factors for diabetic hand sepsis. In this study, 10 a group of Tanzanians with tropical hand infections were compared with a group without infection.8 Significantly associated factors were nerve damage diabetic neuropathy, though this was usually only detectable in the lower limbs ; , insulin treatment, and low body mass index BMI ; . It is likely that the latter two factors and possibly also the first ; are simply reflections of poor blood glucose control, which may be of particular causal significance.

Whittle, J., Steinberg, E.P., Anderson, G.F., Herbert, R. 1 99 1 ; Use of Medicare claims data to evaluate outcomes in elderly patients undergoing lung resection for lung cancer. Chest, 100, 729-734. Wilcox, V.L., KSI, S.V., Idler, E.I. 1996 ; . Self-rated health and physical disability in elderly survivors of a major medical event. Journals of Gerontology: Social Sciences, S I B , S96-104. Wilkinson, T.J., Sainsbury, R. 1998 ; . The association between mortality, morbidity and age in New Zealand's oldest old. International Journal of Aging and Human Developrnent, 46, 333-343 and griseofulvin and flupenthixol, for example, fluphenazine.

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