HORMONAL AGENTS, continued FORTICAL; calcitonin, salmon, synthetic GYNODIOL; estradiol HYDROCORTISONE; hydrocortisone KEY-PRED; prednisolone acetate LEVOTHROID; levothyroxine sodium levothyroxine sodium LEVOXYL; levothyroxine sodium MEDROXYPROGESTERONE ACETATE; medroxyprogesterone acet methylprednisolone NATURE-THROID; thyroid norethindrone acetate ORTHO-EST; estropipate pamidronate disodium prednisolone prednisone PREDNISONE INTENSOL; prednisone PULMICORT; budesonide SYNTHROID; levothyroxine sodium thyroid UNITHROID; levothyroxine sodium VIVELLE; estradiol WESTHROID; thyroid ANDROGEL; testosterone CLIMARA; estradiol CYTOMEL; liothyronine sodium DDAVP; desmopressin acetate DEXAMETHASONE; dexamethasone DIDRONEL; etidronate disodium ESTRACE; estradiol ESTRADERM; estradiol ESTRASORB; estradiol ESTRING; estradiol ESTROGEL; estradiol EVISTA; raloxifene hcl FEMRING; estradiol acetate FEMTRACE; estradiol acetate FIRST-PROGESTERONE; progesterone, micronized FOSAMAX; alendronate sodium FOSAMAX PLUS D; alendronate sodium vitamin d3 GYNODIOL; estradiol G ; - Generic only is covered. Brand-name listed for reference only. 23 1.
1997; 13 2 ; : 73-7 tominaga y, johansson h, johansson h, et al secondary hyperparathyroidism: pathophysiology, histopathology, and medical and surgical management, for instance, brand name.
Received September 5, 2000; revision received April 2, 2001; accepted April 3, 2001. From the Institute for the Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School M.A.M., R.A.L. the Department of Epidemiology M.A.M., M.M. ; and the Department of Health and Social Behavior J.B.S. ; , Harvard School of Public Health; and the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School J.E.M. ; , Boston, Mass. Correspondence to Murray A. Mittleman, MD, DrPH, Cardiovascular Division, Beth Israel Deaconess Medical Center, 1 Autumn Street, Fifth Floor, Boston, MA 02215. E-mail mmittlem caregroup.harvard 2001 American Heart Association, Inc. Circulation is available at : circulationaha.
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Curcumin exhibits a variety of pharmacological effects including antitumor, antiinflammatory, and anti-infectious activities and is currently in clinical trials for AIDS patients. The effects of curcumin have been determined on purified human immunodeficiency virus type 1 HIV-1 ; integrase. Curcumin has an inhibitory concentration50 IC50 ; for strand transfer of 40 microM. Inhibition of an integrase deletion mutant containing only amino acids 50-212 suggests that curcumin interacts with the integrase catalytic core. Two structural analogs, methyl cinnamate and chlorogenic acid, were inactive. Energy minimization studies suggest that the anti-integrase activity of curcumin could be due to an intramolecular stacking of two phenyl rings that brings the hydroxyl groups into close proximity. The present data suggest that HIV-1 integrase inhibition may contribute to the antiviral activity of curcumin. These observations suggest new strategies for antiviral drug development that could be based upon curcumin as a lead compound for the development of inhibitors of HIV-1 integrase. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Micke P, Beeh KM, Schlaak JF, Buhl R. Pulmonary Division, III. Medical Department, Mainz University Hospital, D-455101 Mainz, Germany. Eur J Clin Invest 2001 Feb; 31 2 ; : 171-8 HIV infection is characterized by an enhanced oxidant burden and a systemic deficiency of the tripeptide glutathione GSH ; , a major antioxidant. The semiessential amino acid cysteine is the main source of the free sulfhydryl group of GSH and limits its synthesis. Therefore, different strategies to supplement cysteine supply have been suggested to increase glutathione levels in HIVinfected individuals. The aim of this study was to evaluate the effect of oral supplementation with two different cysteine-rich whey protein formulas on plasma GSH levels and parameters of oxidative stress and immune status in HIVinfected patients. In a prospective double blind clinical trial, 30 patients 25 male, 5 female; mean age + - SD ; 42 9.8 years ; with stable HIV infection 221 + 102 CD4 + lymphocytes L-1 ; were randomized to a supplemental diet with a daily dose of 45 g whey proteins of either Protectamin Fresenius Kabi, Bad Hamburg, Germany ; or Immunocal Immunotec, Vandreuil, Canada ; for two weeks. Plasma concentrations of total, reduced and oxidized GSH, superoxide anion O2- ; release by blood mononuclear cells, plasma levels of TNF-alpha and interleukins 2 and 12 were quantified with standard methods at baseline and after therapy. Pre-therapy, plasma GSH levels Protectamin: 1.92 + - 0.6 microM; Immunocal: 1.98 + - 0.9 microM ; were less than normal 2.64 + - 0.7 microM, P 0.03 ; . Following two weeks of oral supplementation with whey proteins, plasma GSH levels increased in the Protectamin group by 44 + - 56% 2.79 + - 1.2 microM, P 0.004 ; while the difference in the Immunocal group did not reach significance + 24.5 + - 59%, 2.51 + - 1.48 microM, P 0.43 ; . Spontaneous O2release by blood mononuclear cells was stable 20.1 + - 14.2 vs. 22.6 + - 16.1 nmol h-1 10-6 cells, P 0.52 ; whereas PMA-induced O2- release decreased in the Protectamin group 53.7 + - 19 vs. 39.8 + - 18 nmol h-1 10-6 cells, P 0.04 ; . Plasma concentrations of TNF-alpha and interleukins 2 and 12 P 0.08, all 706, for example, lisinopril.
Was higher in sevelamer group [1]. Serum 1, 25 OH ; 2D3 and 25 OH ; D3 levels were not evaluated in this study. Vitamin D deficiency plays a crucial role in the pathogenesis of secondary hyperparathyroidism in dialysis patients. There is no conclusive data regarding the influence of sevelamer therapy on serum 1, 25 OH ; 2D3 and 25 OH ; D3 concentration but results mentioned above may indicate potential suppressive effect of sevelamer on intestinal vitamin D absorption. Sevelamer binds bile acids with high capacity [6]. While witanim D is a fat-soluble vitamin, its intestinal absorption might be impaired in these circumstances. Regarding these data, we believe, that sevelamer presumably depleted 25 OH ; D3 disturbing enterohepatic cycle of vitamin D [7]. As a result of 25 OH ; deficiency, its transformation to 1, 25 OH ; 2D3 was diminished. Consequently we did not observe decrease in PTH concentration despite significant decrease in phosphorus concentration. A decrease of serum 25 OH ; D3 2D3 levels could be an explanation of the lack of PTH decrease [7]. Also Block et al found that PTH concentration was significantly higher in patients treated with sevelamer than with calcium-based phosphate binders [1]. According to study of others [9], we believe that, depletion of 25 OH ; was a primary cause of 1, 25 OH ; 2D3 deficiency. On the other hand, our study showed, that sevelamer therapy restored normal feedback loop from serum 1, 25 OH ; 2D3 on PTH secretion. We suppose that this desired effect was caused by improving of parathyroid gland sensitivity to circulating 1, 25 OH ; 2D3 which had been a result of phosphate decrease [10]. We presume that seasonal variations of 25 OH ; may obscure basic effect of sevelamer on serum concentration of 25 OH ; D3. Our study was performed during the same season in all patients, hence sevelamer-mediating effect on 25 OH ; was noticeable. Apart from anything, we conclude that sevelamer is a very desirable drug for treating hyperphosphataemia in haemodialysis patients. Our clinical experience confirms this valuable virtue. However it should be noticed that sevelamer may potentially cause interactions with common applied drugs.
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Authors' response We are grateful to Drs Budd & Everett for drawing attention to our omission of relationships between non-consultant career grade NCCG ; doctors and other grades in our article. This reflects the changing nature of medical staffing: a significant increase in the number of NCCG doctors has been stimulated by the European Working Time Directive restriction on junior doctors' hours and, for some, the unattractiveness of taking up a substantive consultant post at the earliest opportunity when they perceive that consultants face increasing bureaucracy and impingements on their professional freedom. NCCG doctors indeed have a more complex relationship with other medical colleagues. Trainees and senior psychiatrists tend to have followed more predictable career patterns, whereas a striking diversity of pathways eventually lead a doctor to choose to apply for an NCCG post. Part of the difficulty arises from the fact that there are vast differences in the expectations of NCCG doctors: some see the post as a stop-gap or interval in their career, or have positive reasons for choosing not to proceed to consultant posts; others purposefully seek an alternative route to that grade, or take the job for the considerable financial gains of employment through locum agencies. All these will affect relationships in different ways.
IMITREX QL ; ANXIOLYTICS Note: All oral drugs within this drug class will have no coverage restrictions. alprazolam QL ; buspirone hcl diazepam QL ; lorazepam QL ; SEDATIVE HYPNOTIC DRUGS flurazepam hcl temazepam triazolam SONATA ANTIMANIA DRUGS lithium carbonate lithium citrate CARBAMAZEPINES carbamazepine QL ; TEGRETOL XR ANTICONVULSANT BENZODIAZEPINES clonazepam HYDANTOINS phenytoin QL ; , -sodium extended DILANTIN QL ; VALPROIC ACID AND DERIVATIVES valproic acid DEPAKOTE QL ; SUCCINIMIDES ethosuximide QL ; ANTICONVULSANT BARBITURATES phenobarbital primidone QL ; OTHER ANTICONVULSANTS Gabapentin QL ; LAMICTAL QL ; ZONEGRAN TERTIARY AMINES amitriptyline hcl doxepin hcl imipramine hcl SECONDARY AMINES desipramine hcl nortriptyline hcl SELECTIVE SEROTONIN REUPTAKE INHIBITORS Note: All oral drugs within this drug class will have no coverage restrictions. citalopram soln citalopram hbr fluoxetine hcl fluvoxamine maleate paroxetine hcl LEXAPRO CELEXA PAXIL CR ZOLOFT WELLBUTRIN XL OTHER ANTIDEPRESSANTS Note: All oral drugs within this drug class will have no coverage restrictions. bupropion, -sr mirtazapine nefazodone hcl trazodone hcl EFFEXOR XR ; WELLBUTRIN XL ANTIVERTIGO AND ANTIEMETIC DRUGS prochlorperazine maleate trimethobenzamide hcl EMEND ZOFRAN, -ODT, IN DEXTROSE ANTIPARKINSON ANTICHOLINERGIC DRUGS benztropine mesylate OTHER ANTIPARKINSON DRUGS bromocriptine mesylate carbidopa levodopa selegiline hcl REQUIP STALEVO ANTIPSYCHOTIC DRUGS Note: All oral drugs within this drug class will have no coverage restrictions. clozapine haloperidol thioridazine hcl RISPERDAL QL ; SEROQUEL QL ; ZYPREXA ABILIFY QL ; RISPERDAL QL ; CONSTA XYREM PA ; CNS STIMULANT DRUGS amphetamine salt combo methamphetamine hcl methylin, -er methylphenidate, -er ADDERALL XR METADATE CD, -ER ANTIDEMENTIA DRUGS ARICEPT EXELON NAMENDA DRUGS TO TREAT MULTIPLE SCLEROSIS COPAXONE PA ; DERMATOLOGICAL MEDICATIONS TOPICAL CORTICOSTEROID DRUGS alclometasone dipropionate amcinonide betamethasone dipropionate clobetasol propionate desoximetasone diflorasone diacetate fluticasone propionate triamcinolone acetonide ANTIPRURITIC DRUGS hydroxyzine hcl hydroxyzine pamoate ANTIACNE DRUGS clindamycin phosphate erythromycin base metronidazole 0.75% sod.sulfacetamide sul fur tf tretinoin FINACEA METROGEL, -LOTION ROZEX KERATOLYTIC DRUGS CONDYLOX ANTIPSORIASIS AND ANTIECZEMA DRUGS selenium sulfide TAZORAC DOVONEX TOPICAL DERMATOLOGICAL DRUGS ELIDEL QL ; SCABICIDES LINDANE EAR-NOSE-THROAT MEDICATIONS DRUGS AFFECTING THE EAR a b otic CIPRO HC QL ; CIPRODEX, -OTIC QL ; DRUGS AFFECTING THE NOSE ipratropium bromide ASTELIN NASONEX DRUGS AFFECTING THE THROAT AND MOUTH chlorhexidine gluconate ENDOCRINE MEDICATIONS INSULIN HUMULIN NOVOLIN LANTUS HUMALOG, MIX 75 25 NOVOLOG, -MIX 70 30 ORAL HYPOGLYCEMIC DRUGS glipizide, -er glipizide metformin glyburide, metformin metformin, -er PRECOSE PRANDIN INSULIN SENSITIZERS AVANDAMET AVANDIA GLUCOCORTICOID DRUGS dexamethasone hydrocortisone methylprednisolon e prednisolone prednisone MINERALOCORTICOID DRUGS fludrocortisone acetate THYROID SUPPLEMENTS levothoid levothyroxine sodium levoxyl ANTITHYROID DRUGS propylthiouracil OTHER ENDOCRINE DRUGS ACTONEL DIDRONEL DDAVP PA ; FORTEO SENSIPAR GASTROINTESTINAL MEDICATIONS ANTIDIARRHEAL DRUGS diphenoxylate w atropine FGHP 10 2006 ; -MC and lipitor.
Int. Cl. F16C 13 02 2006.01 F16C 35 00 2006.01 B65G 39 12 2006.01 ; . Head structure for rotatable supporting shafts and the like. Gattrugeri, Giovanni Int. Cl. B65D 81 00 2006.01 ; . A DISPOSABLE CARTRIDGE FOR USE IN MACHINES FOR EXTRACTION AND DISPENSING OF HOT DRINKS. LUIGI LAVAZZA S.p.A.
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The degree of market acceptance of any product candidates that we develop will depend on a number of factors, including: • establishment and demonstration of clinical efficacy and safety; • cost-effectiveness of our product candidates; • their potential advantage over alternative treatment methods; • reimbursement policies of government and third-party payers; and 38 • marketing and distribution support for our product candidates, including the efforts of our collaborators where they have marketing and distribution responsibilities.
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Y Keep windows closed to prevent pollens or mold spores from drifting in to your home, or use air conditioning. y Ride with your car windows closed. y Take prescription medications regularly. Stick to the recommended dosage and watch for side effects. Many allergy medications cause drowsiness, which can be a problem around machinery or while driving. y Don't hang sheets or clothing on clotheslines, where they may collect pollens, dust and molds. y Avoid mowing your lawn, raking leaves and being around freshly cut grass these can trigger hay fever for some people.
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