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Arms, illegal drugs, and narcotics. Further, it is very commendable that influential medical journals like The Lancet contribute to the disclosure of the agenda of organisations that will not contribute to stop such trade. However, I do not understand why your editorial indicates that an advocacy for increased effort against infectious and other poverty-related diseases should be in conflict with a stand against trade of harmful commodities and other important threats to health. It is a well documented fact that infectious diseases represent the greatest disease burden for the poor of the world, and that we in the more-developed world have the most cost-effective interventions. As shown among others by Gwatkin and colleagues, the effect of intervention among the poor will also be largest if more resources are made available for the "unfinished agenda" of prevention and treatment of these diseases. This is also the policy of WHO, as expressed in the World Health Report 1999: "First and foremost, there is a need to reduce the burden of excess mortality and morbidity suffered by the poor . will mean focusing more on interventions that we know can achieve the greatest health gain possible within prevailing resource limits".4 The report goes on to mention that renewed attention is necessary for diseases like tuberculosis, malaria, HIV AIDS, and immunisation programmes, in addition to the diseases of mothers and children. A well accepted ethical criterion for resource allocation in the health sector is first to attend to those with the greatest needs. On the global scale, it is clear that those with the largest deficiencies in terms of access to prevention and care are the poor, and that their greatest and most immediate threats to health come from infectious diseases. I hope The Lancet will not obfuscate this fact by indicating that those who present arguments to this effect serve to create "a manipulated dichotomy in global health policy.

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14: 00 CASE STUDY: Old Compounds New Stories Topical infections- Explore alternative paths to enter the market Re-occurrence & problematic issues in topical infections Progresses on dosage, application and novel delivery methods New treatment options - are new compounds always better? - Utilise existing resources and data to optimize profit Analyse topical infection mortality trends and future treatment: How to meet the unmet needs? Dr. Cees Winnips CEO & Chairman, Necura Pharmaceuticals CASE STUDY: Evaluate a New Class of Antibacterial Agents -Ketolides Overview of the value of ketolides in infectious diseases Evaluate potency studies, mechanism of action, spectrum of activity & costs to manufacture - Potential blockbusters? Profit forecast on ketolide development Combating Gram-positive resistance - How effective are they? Analyse clinical evidence of resistance data Ketolides-telithromycin- a viable new antimicrobial drug class? - Examine results from comparability tests Dr. Andr Bryskier Senior Director, Clinical Microbiology, Aventis Afternoon Tea CASE STUDY: Novel Approaches in Anti-Infective Therapeutics Clinical resistance to b-lactams What are we fighting against? Understanding the molecular basis of PBP-mediated resistance in Gram-positive cocci MRSA infection & b-lactam resistance What is the correlation? Anti-MSRA cephalosporins currently in development Resistant Gram-Negative bacteria, especially Neisseria, Haemophilus, Acinetobacter and Pseudomonas Prospects for new b-lactams dealing with resistant Gram Negative bacteria Professor Malcolm Page Head of Biology, Basilea Pharmaceutica CASE STUDY: R207910 - Promising Compound for the Treatment of Tuberculosis The fight against Tuberculosis: Medical needs -Why the urgency? Discovery of a new class of potent TB compounds - R207910 Examine efficacy studies in the mouse model Clinical analysis of lead candidate Can the treatment paradigm for tuberculosis be changed? Dr. Koen Andries Distinguished Research Fellow, JnJ Pharmaceutical R&D.

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Figure 2.--Patient flow diagram. Reasons for dropouts were illness or health problems 4, and 6 in behavioral, drug, and control groups, respectively depression 1, drug group adverse effects 7, drug group and 4, control group and 1 each for personal reasons and dissatisfaction with progress both in the control group ; . ITT indicates intention-to-treat analysis and neurontin.
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