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OverviewIntroductionIn 2001, the 100 global highest selling drug brands included 18 CV drugs and five diabetes drugs, which generated sales of $41bn and accounted for 29.2% of the top selling drugs. The sheer size of these markets underlines the vital importance of CV and diabetes brands to overall market performance and positioning of major pharmaceutical company portfolios. However, competition is fierce, with patents expiring on several key drugs opeDraws on the 2002 PharmaVitae brief entitled "The Top 100 Drugs of 2001", and provides updated sales to H1 2002Looks at the `winner and losers' of the CV and diabetes markets to analyze the factors driving the dynamics of the markets' highest selling drugsForecasts future trends affecting the sales performance of top-selling products and the resulting impact on their marketing companiesReport HighlightsThe battle of the leading statins, Zocor and Lipitor continues, despite new wars on the horizon generic competition and new `superstatins'The first ARBs, Cozaar and Diovan, still lead the market, although face a growing threat from new more efficacious brands with new indications in the pipelineBMS Sanofi-Synthelabo's antiplatelet drug, Plavix, launched in 1998, experienced one of the highest growth rates following positive results from the CURE trial. Meanwhile, older products with new indications such as AstraZeneca's Seloken, and Aventis' Altace also continue to exhibit strong growth.Reasons to PurchaseAccess insighful analysis of the most recent dynamics in the cardiovascular and diabetes markets, with a view to predicting future trends.Identify the most effective lifecycle management strategies for major brands facing intense competitionBenchmark you marketing and product development strategies against those of the leading performersDRIVERS AND TRENDSIn 2001, the ranking of the 100 highest-selling global pharmaceutical brands included 18 cardiovascular drugs, and five diabetes drugs representing combined sales of $41bn and accounting for 29.2% of the top selling drugs. Sales of cardiovascular drugs were led by two statins, Pfizer's Lipitor and Merck & Co.'s Zocor, which generated sales of $6.4bn and $6.6bn, respectively.The sheer size of these markets underlines the vital importance of cardiovascular and diabetes brands to the overall market performance and positioning of major pharmaceutical company portfolios. However competition is fierce and, with the patent expiry of several key compounds, companies are looking to maximize revenue streams for existing products while examining their pipelines with renewed urgency for potential future blockbuster drugs.This brief is the first in a series of two related reports focusing on sales of leading cardiovascular and diabetes brands. The second title will explore the potential for future blockbusters in these markets and assess their impact on company portfolios and future strategies.Sales OverviewProvides an indepth analysis of the global sales performance in 2000, 2001 and during the first half of 2002 of the leading cardiovascular and diabetes drugs featured in Datamonitor's PharmaVitae brief "The.
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The innovative umbrella contract with the U.S. venture capital firm Oxford Bioscience Partners OBP ; , signed in November 2002, continues to open doors to the U.S. market for DDS. The agreement promotes Evotec OAI as the premier solution provider to emerging OBP portfolio biotech companies. It enables DDS to provide them with integrated drug discovery and development solutions. The agreement was extended in April 2004 to include EVOrationaleTM, Evotec OAI's structure based drug design platform see R& D report page 34 ; . In addition, a new contract with NuVios was added to the existing customer base that includes Artesian, Dynogen and Elixir. A compound has now progressed from Discovery Services to Chemical and Pharmaceutical Development in the collaboration with Artesian that began in 2003. A similar umbrella contract was struck with private venture firm MPM Capital in 2004.
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Charts, tables, figures, figure legends, and footnotes may be smaller in size but must be readily legible. Do not use photo reduction. Prepare all graphs, tables, diagrams, and charts in black ink. The application must contain only material that reproduces well when photocopied or printed in black and white since some reviewers may only receive a printed version. Do not use Internet website addresses to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Moreover, reviewers are cautioned that directly accessing an Internet site could compromise their anonymity. 4.7 Biographical Sketches and potassium, because plsvix 75mg.
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3.5 0.1 ; nary system disorders: Cystitis. Vision disorders: Cataract, Conjunctivitis. Other potentially serious adverse events which may be of clinical interest but were rarely reported 1% ; in patients who received PLAVIX in the CAPRIE or CURE controlled clinical trials are listed below regardless of relationship to PLAVIX clopidogrel bisulfate ; . In general, the incidence of these events was similar to that in patients receiving aspirin in CAPRIE ; or placebo + aspirin in CURE ; . Body as a whole: Allergic reaction, necrosis ischemic. Cardiovascular disorders: Edema generalized. Gastrointestinal system disorders: Gastric ulcer perforated, gastritis hemorrhagic, upper GI ulcer hemorrhagic. Liver and Biliary system disorders: Bilirubinemia, hepatitis infectious, liver fatty. Platelet, bleeding and clotting disorders: hemarthrosis, hematuria, hemoptysis, hemorrhage intracranial, hemorrhage retroperitoneal, hemorrhage of operative wound, ocular hemorrhage, pulmonary hemorrhage, purpura allergic, Thrombocytopenia. Red blood cell disorders: Anemia aplastic, anemia hypochromic. Reproductive disorders, female: Menorrhagia. Respiratory system disorders: Hemothorax. Skin and appendage disorders: Bullous eruption, rash erythematous, rash maculopapular, urticaria. Urinary system disorders: Abnormal renal function, acute renal failure. White cell and reticuloendothelial system disorders: Agranulocytosis, granulocytopenia, leukemia, leukopenia, neutrophils decreased. Postmarketing Experience The following events have been reported spontaneously from worldwide postmarketing experience: Body as a whole: -- hypersensitivity reactions, anaphylactoid reactions Central and Peripheral Nervous System disorders: -- confusion, hallucinations, taste disorders Liver and Biliary system disorders: -- abnormal liver function test, hepatitis non-infectious ; Platelet, Bleeding and Clotting disorders: -- cases of bleeding with fatal outcome especially intracranial, gastrointestinal and retroperitoneal hemorrhage ; -- agranulocytosis, aplastic anemia pancytopenia, thrombotic thrombocytopenic purpura TTP ; -- see WARNINGS. -- conjunctival, ocular and retinal bleeding Respiratory system disorders: -- bronchospasm Skin and Appendage disorders: -- angioedema, erythema multiforme Urinary system disorders: -- glomerulopathy, abnormal creatinine levels.
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