First-hand medical information on the negative effects of the doping drugs used in GDR sports, particularly androgenic steroids, is found in the secret doctoral theses, in some of the scientific reports, and most directly and frankly, in the Stasi reports of some sports physicians. Many of the sports physicians of the GDR broke patient confidentiality and professional secrecy in their reports to the security agents. Moreover, in recent years, several courageous former athletes have publicly described the damages resulting from these drugs, and some have sued the responsible persons. The general prosecutor of a special task force "for governmental and unification criminality" ZERV ; in Berlin is currently investigating the cases of 50 victims of the administration of these drugs without medical requirement or justification and usually also without informed consent.8 Most of the side effects and damages known from the medical literature to occur with various frequencies upon.
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A.1 Community-acquired A.1.1 COPD, Pneumonia: Betalactam with Betalactamase inhibitor [A.1.1 i ; ] with or without Levofloxacin [A.1.1 ii ; ] Macrolide Roxithromucin ; [A.1.1 iii ; ] A.1.2 Urinary tract infections: Nitrofurantoin [A.1.2 i ; ] Nalidixic acid [A.1.2 ii ; ]. Confirm evidence of pyelonephritis and treat accordingly. A.1.3 Skin and soft tissue bone joint: Cloxacillin [A.1.3 i ; ] Clindamycin[A.1.3 ii ; ] Cephalexin [A.1.3 iii ; ]. Necrotizing fascitis: High-dose Penicillin [A.1.3 iv ; ] + Clindamycin [A.1.3 ii ; ] A.1.4 Intra-abdominal and hepatobiliary: Oral Quinolones [A.1.4 i ; ] with Clindamycin [A.1.3 ii ; ] with or without Metronidazole [A.1.4 iii ; ]. A.1.5 CNS: Ceftriaxone [A.1.5 i ; ] or refer to the guidelines under Medical Specialties. A.2 Hospital-acquired A.2.1 CNS: Third-generation Cephalosporins [A.1.5 i ; ] A.2.2 Intra-abdominal and hepatobiliary: Netilmicin [A.2.2 i ; ] + Oflaxacin [A.1.4 i ; ] with or without Metronidazole [A.1.4 iii ; ] A.2.3 Skin and soft tissue bone joint: Clindamycin [A.1.3 ii ; ] Cephalexin [A.1.3 iii ; ]. Necrotizing fasciitis: High-dose Penicillin [A.1.3 iv ; ] + Clindamycin [A.1.3 ii ; ] A.2.4 Urinary tract infection: Netilmicin [A.2.2 i ; ] + Ofloxacin [A.1.4 i ; ] A.2.5 COPD, Pneumonia: Fluoroquinolone Levofloxacin ; [A.1.1 ii ; ] Aminoglycoside Amikacin ; [A.2.2 i ; ] + Cefpirom [A.2.5 iii ; ] with or without Clindamycin [A.1.3 ii ; ].
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RESULTS After the Changes in symptom and LEPS in CP or infertility with CP treatment by EA-10, P5 + Roxithromycin, EA-10, P5 alone, and roxithromyc alone in CP or infertility with CP, remissive rate of symptom was 92 %, 66.67 %, 68.17 %, and 90 %, 61.91 %, 63.64 %, while effective rate of LEPS was 88 %, 57. 14 %, 59.09 %, and 85 %, 52. 38 %, 54. 55 %, respectively. Therapeutic efficacy in group A was significantly higher than that in group B or C Tab 1, 2 and stavudine.
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In several human gastrointestinal neoplasms including hepatitis C virus associated hepatocellular carcinoma, the immunologic type II ; isoform of NOS iNOS ; generates nitric oxide from L-arginine in inflamed tissues and is elevated 26 ; . Nitric oxide causes DNA breaks and enhances DNA mutations, especially in hepatitis C virus associated hepatocellular carcinoma 27 ; . Because cloning and functional analysis of the human iNOS gene promoter have identified several copies of NF-nB response elements and several copies of activator protein 1 binding sites, roxithr0mycin could affect the inactivation of iNOS, as reported in the present study and our former studies 9 ; . Furthermore, iNOS and NADPH oxidase are major sources of reactive oxygen species in experimental hepatocarcinogenesis 28 ; . The produced reactive oxygen species could again secondarily lead to NF-nB activation see Fig. 6 ; . The mechanisms of action for the anti-inflammatory properties of macrolides such as roithromycin are still being investigated, but they are clearly multifactorial 29 ; . Many researchers have shown that an important aspect of inflammation is extravasation of neutrophils into tissues 30 32 ; . Macrolides inhibit the production of many proinflammatory cytokines such as interleukin 1, interleukin 6, interleukin 8, and tumor necrosis factor a, perhaps by suppressing the transcription factor NF-nB or activator protein 1 9 ; . Inhibition of cytokine production has been observed in vitro and also in bronchoalveolar lavage fluid, which contains less interleukin 8 and fewer neutrophils after treatment with macrolides. Thus, at least, inactivation of neutrophils may also be one of the possible mechanisms to explain the effectiveness of rxoithromycin on oxidative stress and NF-nB inactivation. In conclusion, the present study indicates that roxithromycin inhibits oxidative stress, nitric oxide production, and NF-nB activation induced by experimental hepatocarcinogenesis. Because roxithromycin is widely used in clinical practice, it may represent an effective new strategy for human hepatoma therapy.
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