Role of neoadjuvant chemotherapy on hepatic resections for metastases from colorectal cancer M. Arru, F. Milani, L. Aldrighetti, M. Ronzoni, M. Catena, R. Finazzi, G. Ferla Liver resection is the first treatment for patients pts ; with metastases from colorectal cancer and chemotherapy CT ; can increase resectability rate. The impact of preoperative CT on the outcome of liver resections has been evaluated. 61 liver resection for colorectal metastases performed in 57 pts divided in two groups: 22 pts Ch + group ; treated with preliminary CT and subsequent liver resection; 39 pts Ch- group ; treated only with liver resection. No significant differences were observed in postoperative course except for the length of hospitalization, shorter in Ch + group median 8 vs 11 days; p .002 ; . No significant differences were noticed in median disease free survival 15 vs 13 months; p .501 ; , disease free survival at 1 and 3 years 54% and 28% vs 49% and 17% ; , median overall survival 32 vs 30 months; p .373 ; and overall survival rate at 1 and 3 years 93% and 29% vs 88% and 45% ; . In pts with unresectable disease at first observation, neoadjuvant CT allows a surgical treatment with disease free and overall survival rates similar to those of the pts treated immediately with resection. Impact of advanced age on the outcome of liver resections L. Aldrighetti, M. Arru, M. Catena, R. Finazzi, F. Milani, C. Pulitan, G. Ferla A total of 155 consecutive liver resections was divided into two groups: 75 years old [old group O-group ; ] and 75 years old [young group Y-group ; ].The outcome of liver resections was evaluated in terms of postop.
External Committees 1996-1999 American Academy of Neurology representative to the DICOM committee Digital imaging and communications in medicine - The ANSI associated standards committee for medical images ; . University of Rochester representative to the NyserNet 2000 Internet 2 applications committee. American Epilepsy Society Annual Meeting Evening Symposium committee, for example, differin.
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OPTIMIZED FUSION OF NATIVE OR RECONSTITUTED MEMBRANES TO ARTIFICIAL LIPOSOMES FOR SINGLE CHANNEL RECORDING Correa, A.M., Zhou, J.& Agnew, W.S., Cellular and Molecular Physiology, Yale Univ. Sch. of Med., New Haven, CT 06510 We report the efficient fusion of artificial liposomes with either native membrane vesicles or reconstituted liposomes containing purified ion channels, to produce structures suitable for patch clamp recording. Liposomes PE: PS: PC, 5: 4: 1, for the reconstituted material, and PE: PS, 7: 3, for native membranes ; prepared in high ionic strenght buffer 400 mM NaCI, 10 mM Tris-HCI, 1 mM CaC12, pH 7.2 ; and sonicated to clarity are mixed with native or reconstituted membranes to final lipid and protein concentrations of 10 and 0.4 mg ml, respectively. Samples must be briefly sonicated before being frozen at -80 'C and thawed at room temperature. Thawed samples contain bundle-like aggregates of multilamellar vesicles. Subsequent dilution in 250 mM NaCI, 10 mM HEPES, pH 7.2 causes vesicles to grow to final diameters averaging 30-40 jim. The morphology of the vesicle bundles and the efficiency of liposome expansion was dependent on protein concentration and PS content of the samples. The technique was used to record single channel currents from the purified reconstituted Na channel from Electrophorus electricus. Channels were purified by ion exchange and lectin affinity chromatography followed by removing detergent from lipid supplemented samples. Standard patch-clamp recording from excised patches treated with batrachotoxin BTX ; revealed 1-4 or more channels with characteristic BTX-modified properties. Sigmoidal activation with voltage, r 10 and 16 pS ; . Efficiency of seal formation and seal resistance varied with ionic composition: 10-20 GOhm seals were readily formed in NaCI solutions. Fusion of native collagenased membranes from eel electroplax, or from rat skeletal muscle T-tubules permitted recording from excised patches. Intense channel activity observed indicated the presence of a variety of channels in these membranes. Supported by NS 17928 to WSA.
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FC RI ALPHA CHAIN POLYMORPHISMS REFERENCES 1. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease COPD ; and asthma. Rev Respir Dis 136: 225244, 1987. Burchard EG, Silverman EK, Rosenwasser LJ, Borish L, Yandava C, Pillari A, Weiss ST, Hasday J, Lilly CM, Ford JG, and Drazen JM. Association between a sequence variant in the IL-4 gene promoter and FEV1 in asthma. J Respir Crit Care Med 160: 919922, 1999. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, and Lander ES. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 22: 231238, 1999. Conroy MC, Adkinson NF Jr, and Lichtenstein LM. Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release. J Immunol 118: 13171321, 1977. Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet JP, and Capron M. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367: 183186, 1994. Hill MR and Cookson WOCM. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E Fc epsilon RI-beta E237G ; : associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet 5: 959962, 1996. Lai E, Riley J, Purivs I, and Roses A. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics 54: 3138, 1998. Maurer D, Fiebiger E, Reininger B, Wolff-Winiski B, Jouvin MH, Kilgus O, Kinet JP, and Stingl G. Expression of 9. 10.
1. Department of Internal Medicine, 2. Division of Cardiovascular Medicine, University of Michigan Health System and acyclovir.
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This treatment comparison assessed long-term outcomes of coronary artery bypass surgery CABG ; or medical therapy in patients with heart failure, coronary artery disease, and left ventricular systolic dysfunction who underwent cardiac catheterization at Duke University Medical Center from 1969 to 1994. Patients were classified into the medical therapy n 1, 052 ; or CABG n 339 ; group; survival rates adjusted for differences in baseline characteristics ; strongly favored CABG over medical therapy after 30 days to 10 years regardless of the extent of disease p O.OOl, for instance, sccutane drug.
Page 2 - Hospital-Issued Notice of Noncoverage o PRO Review Results: The PRO will send you a formal determination of the medical necessity and appropriateness of your hospitalization, and will inform you of your reconsideration rights. IF THE PRO DISAGREES WITH THE HOSPITAL i.e., it determines that your care is covered by Medicare ; , you will continue to receive acute care services covered under Medicare. You will continue to be responsible for payment of any applicable amounts for deductible, coinsurance, and convenience services or items normally not covered by Medicare. IF THE PRO AGREES WITH THE HOSPITAL, you will continue to receive SNF swing bed services paid under Medicare. You will continue to be responsible for payment of any applicable amounts for deductible, coinsurance, or convenience services or items normally not covered by Medicare and advair.
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