Ince 2001, the Department of Justice DOJ ; has settled seven cases involving allegations of Medicare and Medicaid drug pricing and marketing fraud against six pharmaceutical manufacturers: AstraZeneca, Bayer, Dey, GlaxoSmithKline, Pfizer, and TAP Pharmaceuticals a joint venture of Abbott Laboratories and Takeda Chemical Industries ; .6 Among these are three of the top five companies by sales volume ; in the industry: Pfizer #1 ; , GlaxoSmithKline #2 ; , and AstraZeneca #5 ; .7 The total paid out by these manufacturers to settle these cases is nearly $1.66 billion. Of this amount, roughly $1.23 billion, including $360 million in criminal fines, was returned to the federal treasury; $217 million was returned to state treasuries; and $188 million was paid out to whistleblowers for bringing the allegations to the attention of DOJ. All but one of these cases began as a lawsuit filed under the federal False Claims Act FCA ; by a whistleblower in most cases an employee of the manufacturer ; .8 Remarkably, these recoveries resulted from allegations involving just a handful of drug products Adaat CC, Albuterol Sulfate, Cipro, Flonase, Ipratropium Bromide, Kogenate, Lipitor, Lupron, Paxil, Zoladex ; .9 Press reports suggest that there are numerous cases in the pipeline and that additional settlements can be expected.10 The size of these recoveries, the market share of the firms involved, and the indications of additional settlements to come, suggests that we may be witnessing a sea change in the relationship between Medicaid and Medicare on the one hand and the pharmaceutical industry on the other. Whistleblowers, federal prosecutors, and state attorneys general appear to be on the verge of forcing fundamental changes in the marketing and pricing practices of the pharmaceutical industry, much as the 1992 National Health Laboratories settlement and its progeny led to fundamental changes in the billing practices of the clinical laboratory industry. 11 These settlements are.
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Health record consultation The Department of Health is proposing that the 1999 guidance "For the record managing records in NHS trusts and health authorities" be replaced with a new code of practice that has been developed in conjunction with NHS Connecting for Health. Interested stakeholders are invited to comment on the new code of practice, which can be accessed via PJ Online pjonline links pj ; . STI cases rise Diagnoses of sexually transmitted infections rose by 2 per cent overall between 2003 and 2004, according to figures released by the Health Protection Agency. Diagnoses of gonorrhoea and genital herpes fell in 2004.
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| Adalat dalidagli1. 2. The Office of the Global AIDS Coordinator should cooperate fully with the WHO Pre-qualification Project to expedite approval and prequalification of AIDS medicines. The Office of the Global AIDS Coordinator should immediately issue a blanket waiver of "buy American" restrictions with respect to non-ARV AIDS medicines used preventatively and to treat opportunistic infections. The U.S. should also waive FDA and SDRA approval requirements when the relevant medicine meets internationally recognized quality, safety, and efficacy standards including WHO pre-qualification. The U.S. Congress should mandate the Office of the Global AIDS Coordinator to use its authority to waive data-exclusivity rules barring tentative FDA approval of generic medicines intended for use abroad in PEPFAR and other Global AIDS Initiative programs and waive restrictions allowing purchase of WHO pre-qualified medicines whenever supply shortages from existing single- or double-source producers create the risk of stock-outs and other supply shortages. The Office of the Global AIDS Coordinator should immediately and broadly announce to all relevant embassies and PEPFAR contractees when the FDA has granted tentative approval to generic medicines. In addition, the Office of the Global AIDS Coordinator and its coordinating agencies should be required to immediately authorize procurement of FDA approved AIDS medicines. Procurement of ARVs and other AIDS medicines by the Office of the Global AIDS Coordinator should be driven by the principles of encouraging the existence of multiple producers, affordability, and compatibility with national treatment protocols in focus countries. In general, preference should be given to lower cost producers, generic or originator.
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The Commission asked Dr Diallo to discuss with colleagues in the FAO IAEA Joint Division in Vienna the possibility of organising a consultants' meeting to develop more comprehensive guidelines for completion of the OIE Validation procedures. 7. Production of Foot and Mouth Disease FMD ; inactivated vaccine in primary bovine lingual epithelium cells The Commission reviewed the conclusions and recommendations of the expert who had reviewed the abovenamed dossier. The recommended method of virus propagation for antigen production is the growth of FMD virus in large scale suspension cultures or monolayers using cell lines under sterile conditions. Primary cell culture may be acceptable for vaccine production in some countries but only if the method of production is entirely compliant with GMP, a validated procedure is applied to ensure inactivation of all possible extraneous agents and adequate in-process and final product tests are in place to ensure consistency and safety of the final product. Text to this effect will be added to the Terrestrial Manual chapter. The Commission emphasised that this technique differs significantly from the "Frenkel method" of bovine lingual explant cultures, which method cannot be recommended in any circumstances. 8. OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals mammals, birds and bees ; For this agenda item, the Commission was joined by the Consultant Editor, Dr James Pearson. The Commission considered the revised drafts of those chapters identified for urgent revision: Principles of validation of diagnostic assays for infectious diseases; Principles of veterinary vaccine production; and Foot and mouth disease. The FMD chapter incorporates revisions recommended by the Ad hoc Group on NSP tests see 4.1 above ; , a new section on Vaccine Matching Tests drafted by the OIE Ad hoc Group on Antigen and Vaccine Banks for Foot and Mouth Disease, the use of primary cells for vaccine manufacture see 7 above ; and various other updates including the proposed reinstatement of the liquid-phase blocking ELISA as a prescribed test see Commission report for September 2005 ; . These chapters will be sent to Member Countries for comment soon with a view to proposing them for adoption at the General Session in May 2006. As agreed by the International Committee, revised chapters that are approved at the General Assembly will be updated on the website. The Commission reviewed the status of the sixth edition of the Terrestrial Manual. The first batch of draft chapters had been sent to Member Countries and the second batch will be sent soon. Those authors who have not yet provided an updated chapter would be sent reminders. The Commission agreed that the wording on containment levels in the chapters on FMD, Newcastle disease, avian influenza and classical swine fever, should be harmonised. It also agreed to include text on personal protective equipment in the chapter on avian influenza. A new chapter on test standards for non-human primates would be added to the Terrestrial Manual. The chapter would contain a reference to the 1998 report of the FELASA6 Working Group on non-human primate health. A need was noted to update the recommended test procedures for bovine anaplasmosis, and the Commission would encourage diagnostics companies to submit their validation dossiers for inclusion on the OIE Register. 9. Liaison with other Commissions and Groups 9.1. TERRESTRIAL ANIMAL HEALTH STANDARDS COMMISSION Chapter 1.4.5. International transfer and laboratory containment of animal pathogens The Commission reviewed modifications made by the Ad hoc Group on Biosafety Biocontainment Standard to chapter 1.4.5 of the Terrestrial Code. The revised chapter would be sent to the OIE Terrestrial Animal Health Code Commission. It is designed to complement the redrafted chapter in the Terrestrial Manual.
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In terms of area, Metro Manila, as always, makes up a large amount of sales 44% as of 2002 ; . Contribution of Metro Manila, however, shrank from 46% in 2001; in its place, Luzon excluding Metro Manila ; has increased its contribution from 27.5% in 2001 to almost 29% in 2002. Chart 14; Table 25 and allegra.
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Your family member eats better if alone at the table or with others present. Make certain he or she has good dental hygiene and that dentures fit properly. Avoid distractions such as the television at meal times. Your family member may have likes and dislikes. Try to accommodate them where possible and still maintain proper nutrition. If he or she will only eat one or two foods you may need to use nutritional supplements. Your loved one may become more messy with eating as the disease progresses. Try to accommodate changes in his or her ability to eat. Buy plastic table cloths and offer more finger foods which are easier to eat. If he or she has another illness such as diabetes make certain foods that should not be eaten are not accessible to him or her. Sometimes too many types of food on the plate can be confusing. Limit the choices of food at any given meal. People with dementia may eat more slowly. Offer small portions or have a number of small meals each day instead of three larger ones. Keep healthy snacks where they can be seen. This may prevent hiding or hoarding food and alphagan.
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Rayagada district. Furthermore, the Jan Adalat26 `People's Court ; held by the Naxalites in southern Orissa has helped them enhance their sway. The PWG's `East Regional Committee', with its headquarters at Visakhapatnam in Andhra Pradesh, controls the activities of Malkangiri District in Orissa. Its eastern division in the Srikakulam district of Andhra Pradesh deals with the affairs of the Gajapati and Rayagada Districts in Orissa. The Jhanjavati, Nagavali and Korkonda dalams of the PWG operate in Malkangiri, while the Uddanam dalam is active in the Gajapati District. The Vasadhara dalam operates in the Rayagada District. These dalams recruit locals and send them to the various training centres in Andhra Pradesh. They also concentrate on developing their front organisations, which deal with propaganda work, including pasting of posters, distributing leaflets and conducting meetings. The MCC has a presence in the three northern districts of Orissa: Sundargarh, Keonjhar and Mayurbhanj. While the Gorumahisani, Jharpokharia, Bangiriposi, Bisoi and Chirang Police Stations of Mayurbhanj District have been affected by Naxalite activity, such activity has also been noticed in the Ghantasila Hills of Jharkhand, close to Mayurbhanj. Further, five police stations Birsa, Bolang, Banki, Podia, Gurundia and Sikayatpalli in the Sundargarh District are also affected by Naxalite activity. The Naxalites operate through the Local Regular Guerilla LRG ; squads, which consist of 15-armed cadres each. Above the LRG is the Special Regular Guerilla SRG ; squad with 15 to 30 armed cadres each. Above these are `military platoons' with 30-armed cadres each. Currently, three LRG and ambien.
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Sorafenib BAY43-9006 ; Sorafenib is an oral small molecule tyrosine kinase inhibitor of c-Raf, B-Raf, PDGFR and VEGFR. In 2005, the FDA approved sorafenib to treat adults with advanced renal cell carcinoma. Two trials using sorafenib in advanced clear cell renal carcinoma were conducted in patients who had received one prior systemic therapy. The first trial was a randomized discontinuation of sorafenib to determine the effects on tumor growth in patients with stable disease.61 A total of 202 patients entered a 12week induction phase with sorafenib 400 mg twice daily and were then randomized to sorafenib 400 mg twice daily or placebo. At 24 weeks, 50% of the patients in the sorafenib group were progression-free compared with 18% of the placebo-treated patients P .0077 ; . Median progression-free survival was also greater with sorafenib 23 vs 6 weeks, P .0001 ; . The.
Police seize heap of marijuana Two raids yield two arrests and 225 pounds of pot SCOTT GUTIERREZ THE OLYMPIAN Narcotics detectives seized about 225 pounds of potent "B.C. Bud" early Thursday after arresting two men linked to a marijuana smuggling and distribution ring. The street value of the seized drugs is at least $600, 000. Authorities first raided the rural home of a man suspected of smuggling hundreds of pounds of marijuana from Canada into Thurston County. The bust started about 11: 30 p.m. Wednesday, Thurston County Narcotics Task Force Capt. Jim Chamberlain said. Marijuana grown in British Columbia, called B.C. Bud, is known for being more potent and more expensive than locally grown pot. Johnny J. Morton, 31, was arrested at his home in the 10200 block of Old Highway 99 Southeast. Detectives and SWAT team officers seized two pounds of pot and about $25, 000 in cash, Chamberlain said. Investigators learned of a second home in the 12500 block of Moe-Lar Lane Southwest in Tenino, where most of the contraband was discovered. After obtaining a second search warrant, officers found 10 hockey-equipment bags filled with vacuum-sealed bags of pot, plus 11 marijuana plants, Chamberlain said. The amount of pot confiscated Thursday is worth $600, 000 to $1 million on the street, he said. "When you have information that large quantities of drugs are being brought into your area, you have to act on it, " Chamberlain said. Joel R. Swenson, 22, was arrested at the second home and booked on suspicion of possession with intent to deliver, manufacturing marijuana and conspiracy to deliver a controlled substance. Morton was booked into Thurston County Jail on suspicion of leading organized crime, On the Web Thurston County Narcotics Task Force: olywa lacey gangunit.
P Leandro1, D Konecki2 and I Tavares de Almeida1 1 Centro de Patognese Molecular, Faculdade de Farmcia da UL, Lisboa, Portugal; 2 Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Using a prokaryotic expression system we have characterized two of the most frequent mutant forms of the human phenylalanine hydroxylase enzyme hPAH; EC 1.14.16.1, for instance, adalat dosage.
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