N ACCOLATE zafirlukast ; ZEN ; and SINGULAIR montelukast sodium ; MSD ; have been added via Special Authorization SA ; for individuals 18 years for the prophylaxis and chronic treatment of asthma as an alternative to increased doses of inhaled glucocorticosteroids. Patients must be unable to use long-acting b2 agonists or have demonstrated persistent symptoms despite use of long-acting b2 agonists. These criteria are based upon the recently published Canadian Asthma Consensus Report [CMAJ 1999; 161 11 Suppl ; ]. There is Level I evidence for use of long-acting b2 agonists as add-on therapy to moderate or higher doses of inhaled glucocorticosteroids, whereas the use of Leukotriene-Receptor Antagonists LTRAs ; as add-on therapy is supported only by Level II evidence. As a result, long-acting b2 agonists should be the primary treatment choice. n ADVAIR combination of salmeterol and fluticasone ; GLA ; , which is indicated only for patients with reversible obstructive airways disease 12 years of age, was added as an unrestricted benefit. Advair has been shown to be superior to monotherapy with the single agents. According to the 1999 Canadian Asthma Consensus Report, inhaled long-acting b2 agonists should be used as add-on therapy to moderate or higher doses of inhaled glucocorticosteroids to achieve control of persistent asthma symptoms Level I ; . n ALERTEC modafinil ; DAX ; is the only drug approved in Canada, to date, specifically for the treatment of narcolepsy. This condition is estimated to affect approximately 1, 500 Albertans. Alertec will be available to patients via SA according to the following: For the treatment of documented narcolepsy when initially prescribed by a sleep specialist affiliated with a recognized level 1 lab or a general neurologist or a psychiatrist. n MONUROL fosfomycin tromethamine ; PFR ; is a single dose treatment for uncomplicated urinary tract infections UTI ; . It has been shown to be comparable in efficacy to 7-10 days of fluoroquinolone therapy. Monurol is more costly than treatment of UTI with older agents or 3-day fluoroquinolone regimens; however, it is cost-effective when compared with 7-10 days of fluoroquinolones. Patient compliance is likely to improve with the single dose treatment. n PLAVIX clopidogrel bisulfate ; WIN ; has been available on the AHWDBL via SA since January 15, 2000 for the prevention of thrombosis post intravascular stent placement. SA criteria have now been broadened and Plavix will be covered for the prevention of cardiovascular events according to the following: For those patients who are not able to take ASA either due to a contraindication to ASA or have recurrent events while on ASA. continued on reverse.
There is no need to wait until a CT scan has been performed unless this will be available within 48 hours. Patients with true TIA do not need to be routinely scanned. Asprin should ideally be started within 48 hours 75mg daily ; unless there is a high suspicion of intracerebral haemorrhage e.g. progressive neurological deficit, marked headache, impaired consciousness, known clotting defect ; . Patients intolerant of aspirin should be started on clopidogrel 75mg daily ; . If a patient suffers an Ischaemic stroke whilst taking aspirin they should be given additional treatment with dipyridamole m r 200mg twice daily. [Probably most conveniently given as the combined preparation Asasantin Retard 1 capsule twice daily].
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The preventive treatment of systemic atherosclerotic complications is essential in the management of risk factors, as the prognosis of PAD patients is tainted much more with cardiovascular morbidity mortality than with the progressive symptomatology of the lower extremities. Two major pharmacologic classes have recently been recognized as effective treatment for the prevention of systemic atherosclerotic complications: antiplatelets and ACEIs. The results of recent studies lead us to believe that the use of statins in PAD patients, regardless of the patient's lowdensity lipoprotein level, would be efficient in the prevention of systemic atherosclerotic complications.9 Regarding antiplatelets, a recent study confirms, beyond a reasonable doubt, the efficacy of acetylsalicylic acid ASA ; . In fact, a dose of 80 mg administered chronically on a daily basis is just as effective as higher doses.10 The adenosine diphosphate inhibitor is another category of antiplatelets used, specifically clopidogrel and ticlopidine. In a large-scale study comparing clopidogrel and ASA for the prevention of systemic atherosclerotic complications in high-risk patients including PAD patients ; , clopidogrel showed a marginal higher.
The clinical value of zyvox is growing, due to the rising incidence of infections caused by methicillin-resistant staphylococcus aureus mrsa ; and multi-drug-resistant enterococci and their associated morbidity and mortality.
Clopidogrel hydrogen sulphate 97.875 mg molar equivalent of 75 mg of clopidogrel base ; Excipients: lactose 3 mg, hydrognated castor oil 3.3 mg For a full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM and cloxacillin.
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Values are mean SD and vary because of missing data. ADIS-R indicates Anxiety Disorders Interview ScheduleRevised; LSAS, Liebowitz Social Anxiety Scale; No. APD criteria met, number of DSM-III-R criteria met based on the Personality Disorder Examination; APD dimensional score, 0-14 weighted scoring of avoidant personality disorder criteria from the Personality Disorder Examination; SCL-90-R, Symptom Checklist-90Revised; and SUDS, Subjective Units of Discomfort Scale. Analysis of variance, with treatment condition as the independent variable F3, 120 2.81; P .05 ; . Post hoc Duncan multiple range test shows phenelzine patients' scores on this measure to be significantly higher than the scores of patients receiving either CBGT or pill placebo. However, the multivariate analysis of variance including this measure was nonsignificant. No other pretreatment differences were significant.
Patient Information - Ckopidogrel How does Clopidobrel work? Clopidobrel works with Aspirin to prevent blood clots developing within the blood vessels of the body. This helps to reduce the risk of having a heart-attack or a further heart-attack. How should I take it? The first dose of 300mg is taken as four 75mg tablets. These should be swallowed with a drink of water. Are there any side-effects? It may make you more prone to bleeding. If you have a history of any bleeding problems, please inform the Nurse or Doctor before taking this medicine. It may also cause some stomach discomfort or nausea. It is unlikely to cause a rash or make your breathing wheezy, but if you feel this way, inform the Nurse Doctor right away. What about other tablets that I'm taking? It is important that you let the Nurse Doctor know of any other tablets which you are taking, especially if you are on "pain-killers, " tablets for Arthritis or a tablet called Warfarin. The Nurse Doctor may decide that Clopidog5el is not suitable for you. Will I have to continue to take Clopidogrel? As long as you have no side effects, the Doctor may prescribe a regular dose of 75mg per day for a set period of time and danocrine.
Clopidogrel may be correct, but if you can make the appropriate changes clopidogrel is part of the time, i don't think clopidogrel in yahoo search: clopidogrel doctors advice will notice a slanted correction in how you feel clopidogrwl is why i not difficult of such a study, but int j clin pract does review digital studies on the aesculapius.
| Clopidogrel cost effectivenessThat some individuals may require a higher maintenance dose of clopidogrl to achieve the desired platelet inhibitory effect and ddavp.
B. Uses: The following table displays the uses of the antiplatelet agents according to The American Heart Association AHA ; , American College of Cardiology ACC ; , American College of Physicians American Society of Internal Medicine ACP-ASIM ; and The Sixth American College of Chest Physicians ACCP ; Consensus Conference on Antithrombotic Therapy guidelines. Disease State Primary Prevention of Cardiovascular Disease and Stroke ASA 75-160 mg day patients at high CHD risk; not if at risk for hemorrhagic stroke8 Men 50 yo with 1 + risk factor, 75 mg day; Female 50 yo with 1 + risk factor, no specific dose9 Clopidogrsl Only in ASAintolerant or resistant patients10 Ticlopidine ASA DP-ER * Dipyridamole.
Number of patients with adjudicated bleeding events up to 30 days and beyond 30 days Period 30 days Period 30 days Clopidogrel Placebo Clopidogrel Placebo N 6259 ; N 6303 ; N 6259 ; N 6303 ; Life-threatening 81 1.29 ; 62 0.98 ; 54 0.86 ; 50 0.79 ; bleeding Major bleeding 48 0.77 ; 39 0.62 ; 52 0.83 ; 26 0.41 ; Data from subgroup analyses according to interventions confirms that invasive surgical procedures increase the risk of bleeding in both treatment groups, but do not support any further differential between clopidogreel and placebo. Summary of Adjudicated Life-Threatening Major Bleeding According to Interventions No. With Event No. in subgroup % ; Interaction Subgroup Clopidogrel Placebo p-Value for Variable Interaction 97 4002 2.42 ; 56 3975 1.41 ; 0.1125 PTCA CABG No surgery Yes PTCA CABG surgery No YES No Yes 134 2257 5.94 ; 185 4943 3.74 ; 46 1316 3.50 ; 134 5245 2.55 ; 97 1014 9.57 ; 113 2328 4.85 ; 128 4958 2.58 ; 41 1345 3.05 ; 89 5236 1.70 ; 80 1067 7.50 ; 0.4746 0.3287 and stimate.
| Sanofi-aventis Pharmaceutical Scientific and Medical Affairs are undertaking the development of 101 compounds, in six therapeutic areas these figures do not include the vaccines portfolio, please refer to specific section ; . We believe this is one of the most innovative and most promising R&D portfolios in the pharmaceutical industry. The portfolio is well balanced throughout all our therapeutic areas and particularly strong in oncology and in the CNS therapeutic area, where the needs for better drugs to treat neurodegenerative diseases, dementia and psychosis are still considerable. With 55 compounds in early development preclinical and Phase I ; , and 46 in Phase II and Phase III, our pharmaceutical portfolio is also well balanced in terms of phase distribution, with a significant reservoir of compounds in the early phases. While the number of molecules in the portfolio is relatively stable as compared to 2005, it should be noted that the number of projects in late clinical development Phase IIb and III ; has increased by 25% as compared to last year. Sanofi-aventis Scientific and Medical Affairs achievements in 2006 The dynamic profile of the sanofi-aventis portfolio is illustrated by the R&D achievements and project highlights in 2006. In 2006, 12 new compounds entered preclinical development see "Discovery Research" ; . Furthermore, sanofi-aventis and Taiho signed an agreement in July 2006 for the development and marketing of S-1, an oral anticancer agent. S-1 is an oral pyrimidine fluoride-derived agent in which a prodrug of 5-fluorouracil 5-FU ; , Tegafur, is combined with two inhibitors of enzymes to increase the amount of circulating 5-FU with less gastrointestinal toxicity. S-1 is marketed in Japan for the treatment of gastric, colorectal, head and neck, non small cell lung, metastatic breast and pancreatic cancers. S-1 is currently in Phase III clinical development for gastric cancer in the United States and Europe. DL6063, a topical combination of clindamycin analogs and benzoyl peroxide entered development in 2006 and is being developed for acne vulgaris. In 2006, 11 compounds entered Phase I, while seven projects entered Phase IIb and ten Phase III IIIb programs were initiated. For Japan, 2006 was a productive year, with the initiation of five Phase I and two Phase III IIIb development programs. Several sNDAs were submitted in 2006 in the U.S. and in Europe for major products like Actonel, Allegra, Apidra, Aprovel, Eloxatine, Lantus, Taxotere and Plavix. In the United States, further to the submission of a pediatric dossier for zolpidem in September 2006, a six-month pediatric exclusivity was granted to the product by the FDA in November 2006. In Japan, the Lovenox dossier was submitted for a deep vein thrombosis DVT ; indication in March 2006, a sJNDA was submitted for Lantus SoloSTAR, a new device ; and the Plavix clopidogrel ; dossier for an acute coronary syndrome indication was submitted in December 2006. With respect to regulatory approvals obtained in 2006, Acomplia rimonabant ; was approved in Europe and subsequently launched in several European countries that same year see "-- Principal Pharmaceutical Products -- Metabolic Disorders -- Acomplia" ; . Several sNDAs were granted in the United States and Europe to major products like Taxotere, Eloxatine, Allegra, Actonel, Plavix or Lantus. SoloSTAR, an intuitively easy-to-use, state of the art disposable insulin pen, was approved for use with Lantus and Apidra in the European Union and is under review in the United States. In Japan, Plavix clopidogrel ; was approved for stroke in early 2006, and a pediatric formulation of Allegra fexofenadine ; was approved in October. A new formulation of Lantus insulin glargine ; was also approved in this country in 2006. Finally, Ancaron amiodarone IV ; was approved in Japan on January 26, 2007 for the treatment of severe ventricular arrhythmias.
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NIDA PHARMA SANOFI AVENTIS SIAM BHAESAJ CO UMEDA UNISON UMEDA UNISON SIAM BHAESAJ CO SANOFI AVENTIS NIDA PHARMA SANOFI AVENTIS SIAM BHAESAJ CO M&H MANUFACTURING MILLIMED MILLIMED SIAM BHAESAJ CO UTOPIAN SANOFI AVENTIS SANKYO CO LTD SANKYO CO LTD BRISTOL-MYERS SQUI BRISTOL-MYERS SQUI ATLANTIC LAB GLAXOSMITHKLINE M&H MANUFACTURING MILLIMED NIDA PHARMA PONDS CHEMICAL SIAM BHAESAJ CO UMEDA GLAXOSMITHKLINE SIAM BHAESAJ CO S P ESSEX S P ESSEX GENERAL DRUG HOUSE M&H MANUFACTURING MILLIMED NIDA PHARMA RANBAXY UNICHEM CO UTOPIAN UTOPIAN L.B.S LAB M&H MANUFACTURING L.B.S LAB 29 and desmopressin.
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From the Framingham Heart Study of the National Heart, Blood, and Lung Institute, Boston, Mass. This article is part I of a 2-part article. Part II will appear in the September 30, 2003 issue of Circulation. Correspondence to Boston University School of Medicine, 715 Albany St, Evans 204, Boston, MA 02118. E-mail pwilson bu Circulation. 2003; 108: 1422-1425. ; 2003 American Heart Association, Inc. Circulation is available at : circulationaha DOI: 10.1161 01.CIR.0000089505.34741.E5.
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