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Companies. Unigene's recombinant salmon calcitonin product is approved in the US, but would not be automatically substitutable in the US for Miacalcin. Exelon. The active ingredient in Exelin is covered by a compound patent granted to Proterra AG ; , which in the US presently expires in August 2007, and has been determined by the FDA to qualify for patent term extension until 2012, and which expires in 2011-13 in the major markets. In addition, we hold an isomer patent on Exflon which expires in 2012-14. Dr. Reddy's, Sun Pharmaceuticals and Watson Pharmaceuticals have filed applications to market a generic version of Exellon in the US. Together with Proterra, we have sued all three parties for patent infringement. Focalin. The drug dosage form of Focalin and its use in attention deficit hyper-activity disorders are covered by patents granted to Celgene Corporation and licensed to us ; through 2015 in the US and 2018 in other markets. Teva has challenged these patents and has filed an application for a generic version of Focalin in the US. Together with Celgene, we have sued Teva for patent infringement under a use patent. Trileptal. Patent protection for Trileptal's active ingredient has expired in major countries. In the US, New Chemical Entity data exclusivity under the Hatch-Waxman Act of 1984 has expired in 2005. We have also pending patent filings relating to our marketed formulations of Trileptal, which, if granted, would expire in 2018 in major countries, including the US. In Europe this formulation patent is being challenged by three generic companies. Starlix. The active ingredient in Starlix is covered by Ajinomoto patents. The basic US patent will expire in 2009. Several parties have informed us that they have filed an ANDA application to market a generic version of Starlix in the US upon expiration of the basic patent in 2009. In Europe basic compound protection exists in Germany, France, the UK and Switzerland and will expire in 2011. Foradil. Patent protection for Foradil's active ingredient has expired in major countries. In the US, Hatch-Waxman data exclusivity is currently scheduled to expire in February 2006. Voltaren. Voltaren is off-patent. As a result, revenue from Voltaren has declined, and may decline significantly further over the next few years. Famvir. The active ingredient in Famvir is covered by a compound patent which expires in 2010 in the US, in 2008 in Europe and 2006 in Canada. Other method of use patents expire in 2014 and 2015. Teva has challenged these patents in the US and has filed an application for a generic version of Famvir in the US. We have sued Teva in the US for infringement of the compound patent. Zaditor Zaditen. Apotex has filed for approval for a generic version of Zaditor in the US. The Zaditor formulation is covered by a patent in the US. We sued Apotex for patent infringement. However, we subsequently withdrew our suit and there is now no lawsuit pending. Price controls and other pressures may prevent us from setting prices for our products at levels high enough to earn an adequate return on our investments in them. In addition to normal price competition in the marketplace, the prices of our Pharmaceuticals Division's products are restricted by price controls and other pricing pressures imposed by governments and health care providers in most countries. Price controls operate differently in different countries and can cause wide variations in prices between markets. Currency fluctuations can aggravate these differences. The existence of price controls and other pricing pressures can limit the revenues we earn from our products and may have an adverse effect on our business, financial condition or results of operations. Direct efforts to control prices. United States. In the US, ongoing political debates over prescription drug pricing and recent Medicare reform legislation will increase pricing pressures. In particular, recent Medicare 8 and floxin. Patterns of Fluid Intake, continued Many parents restrict their child's fluid intake in an attempt to stop enuresis. A better approach might be to balance the daily fluid intake during the morning and daytime. This will decrease thirst at night and limit the nocturnal challenge to the bladder. Developmental Delay Children reach developmental milestones at different rates. Bladder control requires very complex coordination between the nerves and the muscles. Other factors that might play a role in a child developing normal bladder control include stress and social pressures. A child with enuresis may be subjected to embarrassment, punishment, and even abuse. The anxiety and fear that occurs may only hinder the development of bladder control. Functional Bladder Capacity In general, children with enuresis have smaller bladder capacities compared to children who do not have enuresis. The anatomic capacity is the same in enuretic and nonenuretic children. This means that both types of bladders have the potential to hold the same amount of urine. However, how much a child is actually able to hold in the bladder, or the functional capacity, is less in children with enuresis. Children with enuresis do not have smaller bladders. They are just unable to hold the same amount of urine as non-enuretic children. It is not known exactly why this occurs. Infections Although urinary tract infections in children can cause wetting episodes, they are not a common cause of enuresis. Chronic bacterial infections in the bladder and pinworm infections of the bowels are easily diagnosed and treatable causes of enuresis. The MDCs are based at the major USA and UK sites and are aligned with the following therapeutic areas: Cardiovascular Metabolic Infectious Diseases including Diseases of the Developing World DDW ; Musculoskeletal Inflammation Gastrointestinal Urology Neuroscience Psychiatry Neurology ; Oncology Respiratory. These teams are responsible for maximising the worldwide development opportunities for each product within their remit so that all the information needed to support the registration, safety programmes, pricing and formulary negotiations is available when needed. Commercial input from Global Commercial Strategy ensures that regional marketing needs are integrated into any development plans at an early stage. In addition, R&D is investigating new ways of operating to enable it to respond to the variety of external pressures on the industry, such as increasing regulatory stringency, so that it is positioned to ensure that effective new medicines reach patients as soon as possible. GSK believes that pharmacogenetic research, which correlates genetic data with response to medicine, will help to reduce pipeline attrition and improve productivity. R&D is collecting DNA samples in clinical studies to identify pharmacogenetic information that can help predict a patient's response. This information is intended to define patient groups likely to gain benefit from treatment, or to suffer a side effect, as the compound progresses through development in the clinic. Ultimately, pharmacogenetics promises to provide physicians with information to help them select the medicine and dose most likely to benefit their patient. During 2005, R&D has taken several approaches to improving productivity in clinical trials, including an increasing use of countries outside Western Europe and the USA and the introduction of direct electronic data capture in most new clinical trials. These improvements in productivity will continue going forward. All clinical trials sponsored by GSK, irrespective of where they take place, are conducted according to international standards of good clinical practice and applicable laws and regulations. The protocols are reviewed by the external regulatory agencies in the relevant countries where required and all protocols are considered by an Ethics Review Committee, whose remit covers the site where the study will take place. Safety data is routinely collected throughout development programmes and is reported to national and regional regulatory agencies in line with applicable regulations. The GSK Global Safety Board is responsible internally for approving pivotal studies and investigating any issues related to patient safety arising during the development programme. During 2005, GSK took a further step in making information from its clinical trials widely and easily available by extending its Clinical Trial Register, a public website on which clinical trials data are published. Regulatory authorities will continue to be informed of the data generated so they may be reassured of the safety and efficacy of GSK's products. The Clinical Trial Register will enhance the ability of clinicians to make informed clinical judgements to benefit their patients and fluoxetine, because corp electricity exelon. Ter health for individuals and progress in medicine by developing superior pharmaceutical products." To achieve this mission, our vision at Takeda involves realization of the following specific management priorities. Yasuchika Hasegawa President and Chief Operating Officer.

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Implementation Status Recommendations Fully Part I: Is the process of awarding management consulting contracts fair and open? 1. Ministries should ensure staff are aware of, and follow, government policy for awarding service contracts. This could be done by ensuring staff are aware of the expert assistance, information sources and training opportunities available to them and through the use of a contract information sheet when documenting the awarding of a contract. This sheet should include a checklist composed of all government policy relating to 1 ; the exceptions to competitive awarding and 2 ; the notice of intent requirements, and should require the contract manager to describe how the chosen criterion has been met. 2. Ministries should encourage the use of bidders' lists that are established through an openly advertised means. 3. Ministries should establish adequate systems for ensuring that relevant contract documentation is maintained. 4. Government should review the $25, 000 threshold and the rules surrounding the exceptions to competitive awarding, to assess whether they lead to best value and represent a reasonable balance between administrative efficiency and fairness. 5. Government should ensure that a number of direct award contracts are randomly audited each year, to check that these contracts are being awarded according to government policy. Awareness Compliance Substantially Partially Alternative Action Not Applicable. Exelon electric

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Benefit, Program, or Requirement Description HNE requires prior approval for the following device: Saunders Cervical Hometrac HNE will cover only one surgical procedure per lifetime for the surgical management of morbid obesity. "Lifetime" refers to the life of the covered member. The following injectable drugs require Prior Approval. They are part of your medical benefit, not your prescription drug benefit. Orencia Rituxan Prior Approval required for treatment of rheumatoid arthritis only ; Tysabri HNE covers Gardasil Vaccine for the prevention of Human Papillomavirus HPV ; in females aged 9-26. HNE covers Zostavax Vaccine for the prevention of shingles for members aged 60 and older. See Page 3 and lopressor.
Noon - 5: 30 Registration, Exhibits, Media Fair, Silent Auction 2: 00 - 3: General Session Carol Clements, Chairperson, National Fuel Funds Network Valeria Bullock, PECO Energy, an Exelon Company and Joseph Guarinello, HeartShare Human Services of New York, 2006 Annual Conference Co-Chairs George Coling, Executive Director, National Fuel Funds Network 3: 00 - 3: Networking Session 3: 30 - 5: Hot Topics Roundtables Join a table of colleagues and a presenter for twenty minutes of discussion or hands-on demonstration, and then move on to another table. Tentative Topics: Royalty In Kind Update Energy Hog Update Utility Shutoffs -- A New Strategy in Iowa Direct Mail Coordination -- Finding Economies of Scale Within NFFN Statewide Public Policy Dialogues Statewide Fuel Funds -- A Resurgence Venezuela Citgo Discount Heating Oil Deal Bulk Purchasing Programs -- Do They Work? Arreage Management Preventing Home Fires Price Caps Lifting 5: 30 - 7: Reception Victorine Q Adams Award, Corporate Excellence Awards, Sister Pat Kelley Award.

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