1. Wiswell TE et al. Delivery room management of the apparently vigorous meconium-stained neonate: results of the multicenter, international collaborative trial. Pediatrics 2000; 105: 1. Apgar V. A proposal for new method of evaluation of the newborn infant. Anesth Analg 1953; 32: 260. Ballard JL et al. New Ballard Score, expanded to include extremely premature infants. J Pediatr 1991; 119: 417-423. Cornblath M. Neonatal hypoglycemia. In Donn SM, Fisher CW, editors. Risk management techniques in perinatal and neonatal practice. Armonk, NY: Futura; 1996. 5. Klaus MH, Fanaroff AA. Care of the high-risk neonate, 4th ed. Philadelphia: WB Saunders, 1993. 6. American Academy of Pediatrics, Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia. Practice parameter: management of hyperbilirubinemia in the healthy.
Effects of insulin signaling failure on learning abilities and on neuronal activity in animal models of type 2 Diabetes Supervisors: Dr. Christian Holscher, Dr. Victor Gault Level: PhD Background to the project In type 2 diabetes, the insulin signaling cascade is dysfunctional and causes several physiological complications. One of the effects is that insulin receptors on neurons desensitise, and that neuronal activity and survival is compromised. It has been discovered recently that diabetes type 2 sufferers have an increased risk of developing Alzheimer's disease Luchsinger et al., 2004 ; . It is known that neurons carry insulin receptors, and it appears that the desensitisation of these receptors increases neurodegenerative processes Hlscher, 2005 ; . The project will analyse to what degree the ability of animals with type 2 diabetes to learn novel tasks is affected. Several learning tasks will be used to identify how short-term, longterm, and working memory is affected in different age groups. Tests that will be used are spatial cognition and navigation tasks such as the water maze and radial arm mazes, motor tasks, exploratory tasks. In addition, the neuronal activity and the synaptic activity of type 2 diabetic animals will be tested to investigate how the chronic alteration of insulin signaling will affect neurons. Previous work has shown that insulin receptors play a role in controlling transmitter release and synaptic plasticity. It will be tested to what degree synaptic plasticity is affected in transgenic mice. Synaptic plasticity is important for the development of memory, and impairments in synaptic plasticity will indicate that the cellular systems that underlie memory formation have been affected. Objectives of the research Transgenic mice and mice fed a diet that induces type 2 Diabetes will be tested in learning tasks at several ages. Some animals will receive insulin like analogues to control the blood sugar, while others will not receive such drugs. It will be analysed how the learning ability of different age groups correlates with age and with the amount of plaque formation in the brain. Tests that will be employed are Open Field assessments of motor activity and of exploratory behaviour, spatial tasks such as the 8-arm maze and the water maze, the T-maze a working memory task ; , and several conditioning tasks to analyse nonspatial and temporal learning ability. Synaptic activity and the inducibility of synaptic plasticity will be tested in vivo by electrophysiological methods that stimulate neuronal activity and monitor synaptic activity. The accumulation of amyloid in the brains of diabetic mice will be tested using histological immunochemical methods and microscopy. References Hlscher C 2005 ; Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev Neurosci 16: 181-212. Luchsinger JA, Tang MX, Shea S, Mayeux R 2004 ; Hyperinsulinemia and risk of Alzheimer disease. Neurology 63: 1187-1192, for example, felodipine interaction.
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Figure 5. Effect of grapefruit juice on mean felodipine plasma concentrations. Felodipkne plasma concentrations were measured after the oral administration of 10 mg felodipine with either water ; , after the first 8-oz glass of grapefruit juice ; , or after 5 d of thrice daily administration of grapefruit juice ; . Bars indicate standard errors. Effect of Grapefruit Juice on CYP3A 2549.
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28. Kario K, Shwartz JE, Pickering TG. Changes of nocturnal blood pressure dipping status in hypertensives by nighttime dosing of alpha-adrenergic blocker, doxazosin: results from the HALT study. Hypertension. 2000; 35: 787794. DeQuattro V, Lee DD, Allen J, Sirgo M, Plachetka J. Labetalol blunts morning pressure surge in systolic hypertension. Hypertension. 1998; 11 Suppl I ; : 198201. 30. White WB. Circadian variation of blood pressure: clinical relevance and implications for cardiovascular chronotherapeutics. Blood Press Monit. 1997; 2: 4751. Mclay JS, MacDonald TM, Hosie J, Elliott HL, and on behalf of the Lagimax Group. The pharmacodynamic and pharmacokinetic profiles of controlled-release formulations of felodipine and metoprolol in free and fixed combinations in elderly hypertensive patients. Eur J Clin Pharmacol. 2000; 56: 529535. Meredith PA. Intrinsically long-acting agents compared with long-acting chronoformulations. Blood Press Monit. 2000; 5 Suppl 1 ; : S25S30.
| Felodipine richmondAetiopathogenesis The aetiopathogenesis remains unclear, but minor head injuries or undetectable brain damage, or refined sugar and food additives make some children hyperactive and inattentive. Overactivity can also be caused by external factors, or factors affecting parents, the child or the childparent relationship. There is also a familial predisposition and fenofibrate.
Postoperative atrial fibrillation: A prospective, randomized pilot study. American Heart Journal. 2000; 140 6 ; : 871877. Lee JY, Greene PG, Douglas M, et al. Appointment attendance, pill counts and achievement of goal blood pressure in the African American Study of Kidney Disease and Hypertension Pilot Study. Control Clin Trials 1996; 17 4 Suppl ; : 34S-39S. Leehey DJ and Hartman E. Comparison of diltiazem and hydrochlorothiazide for treatment of patients 60 years of age or older with systemic hypertension. J Cardiol 1988; 62 17 ; : 1218-23. Leeman M and Degaute JP. [Treatment of arterial hypertension after surgery of the abdominal aorta: comparison of captopril and nifedipine administrated sublingually]. Arch Mal Coeur Vaiss 1993; 86 8 ; : 1267-8. Leeman M and Degaute JP. Invasive hemodynamic evaluation of sublingual captopril and nifedipine in patients with arterial hypertension after abdominal aortic surgery. Crit Care Med 1995; 23 5 ; : 843-7. Leenen FH, Burns RJ, Myers MG, et al. Effects of nifedipine versus hydralazine on sympathetic activity and cardiac function in patients with hypertension persisting on diuretic plus beta-blocker therapy. Cardiovasc Drugs Ther 1990; 4 2 ; : 499-504. Leenen FH, Logan AG, Myers MG, et al. Antihypertensive efficacy of the calciumantagonist felosipine in patients with persisting hypertension on betaadrenoceptor blocker therapy. Br J Clin Pharmacol 1988; 26 Nov ; : 535-545. Leenen FH, Myers MG, Joyner CD, et al. Differential effects of once-daily.
The IFCS recommended that all countries prepare a National Profile on the Infrastructure for the Sound Management of Chemicals as a basis for setting priorities for establishing and strengthening capacities and capabilities for chemical safety. The IPCS is collaborating with the United Nations Institute for Training and Research UNITAR ; and the other organizations of the IOMC to promote and support the development of these National Profiles and the organization of national priority-setting workshops. Each organization is expected to promote chemical safety capacity building in countries relevant to its own sector of responsibility, such as agriculture, environment, health and industrial development. Through the Dutch-funded national training project, the IPCS is promoting advocacy and awareness on chemical safety matters among senior decision-makers in developing countries through intensive briefing and awareness-building sessions and organizing training courses on chemical safety and management for senior professionals in 15 developing countries. The IPCS has also prepared a Guideline on Key Elements of a National Programme for Chemicals Management and Safety, which will form one of a series of guidance materials being developed by UNITAR and other IOMC organizations to support chemical safety building in countries and tricor, for example, feloipine and grapefruit.
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FAMILY HEALTH CENTERS OF SAN DIEGO 1809 National Ave., San Diego, CA 92113 619 ; 515-2300 Website: fhcsd HCH Project participants receive primary health care including dental and vision care ; , mental health services and substance abuse treatment. In addition, HCH offers outreach, case management and referrals to mental health, substance abuse recovery, social services, entitlement, housing and employment resources. Health care services are offered at 33 clinics throughout San Diego county and urispas.
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By Cheryle B. Gartley President & Founder Simon Foundation for Continence It is rumoured that men do not enjoy delving into emotions, nor do they appreciate surprises or feeling out of control -all things people with incontinence experience. Coping with a misbehaving bladder means experiencing a wide range of emotions; chief among them is a fear of being wet in public. Feelings caused by incontinence such as embarrassment and the desire to seek isolation lead to changes in selfconfidence. Although uncomfortable, focusing on feelings about incontinence may help you prepare for yours reactions to a misbehaving bladder. Toilet training is important in American culture. Everyone has heard someone say "good boy" or "bad girl" depending on the success the child is having learning bladder control. Given society's fixation on this little muscle, is it any wonder that incontinence is an emotional issue? Often individuals do not recognize the impact of incontinence until they realize the activities they have discontinued golfing, attending sporting events, or even playing poker ; due to the fear of not having immediate access to a bathroom. Anger, depression, and frustration are all common responses to incontinence. Interestingly, research shows that the amount of leakage experienced is not related to the emotional distress a person feels. No one will claim that a misbehaving bladder is not embarrassing; but there are many occasions for embarrassment in life spilling coffee, whiffing a golf ball, tripping over microphone cords ; most people cope and move on. Coping is something we don't notice unless a problem continues. Much can be done about incontinence, but still millions will not be completely cured; thus learning good coping skills can avoid incontinence taking up unnecessary emotional energy. It is helpful to think in terms of both coping with the dread of what might happen, and cop Continued on page 4 and flupenthixol.
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