Merck lobbies to require cervical-cancer vaccine for schoolgirls By LIZ AUSTIN PETERSON Associated Press Writer 30 January 2007 AUSTIN, Texas AP ; - Merck & Co. is helping bankroll efforts to pass state laws requiring girls as young as 11 or receive the drugmaker's new vaccine against the sexually transmitted cervical-cancer virus. Some conservatives and parents'-rights groups say such a requirement would encourage premarital sex and interfere with the way they raise their children, and they say Merck's push for such laws is underhanded. But Merck, which is headquartered in Whitehouse Station, N.J., said its lobbying efforts have been above-board.
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There are obvious advantages and disadvantages in studying a group of healthy elderly men and women who also happen to be well educated and economically secure. From a public health perspective, it might be preferable to develop a clear picture of the extrinsic factors affecting the aging process, such as diet and psychosocial factors, for the entire elderly population, in order to characterize the risks for increased morbidity within that population, and to develop effective programs to treat, delay, or prevent age associated morbid conditions. However, because of the very heterogeneous nature of the elderly population in the U.S., a much larger sample would need to be recruited to identify certain risk factors unique to the elderly compared with younger adults. We fully realize that we have an unrepresentative sample of elderly individuals, so that it may be difficult to generalize our findings to the entire elderly population. On the other hand, by selecting a healthy elderly sample to study we have eliminated much of the increased variance seen in the measurement of virtually any parameter in the general elderly, for example, dietary intakes and organ function. Both cross-sectional and longitudinal studies, showing mean values for cohorts, seem to indicate that many organ functions and metabolic parameters decline with age as does the dietary intake of most nutrients. However, if one follows individual subjects longitudinally, a number of them, including some elderly subjects show no decline in functional status with age. Thus, one needs to separate "successful" aging from "usual" aging. In other words, what has been described in cross-sectional and longitudinal studies to date is "usual" aging, incorporating the effects of pathophysiology and life style diet, exercise, smoking and drinking habits, and psychosocial events ; . Selected individuals, especially those free of risk factors such as smoking, hypertension, diabetes, or hyperlipidemia, may show little or no change in organ function with age. It has been suggested that what is needed is to examine more carefully what determines "successful" aging so that this kind of life style and disease prevention can be advocated and promoted. This approach to a longitudinal study, with careful analysis of differences in nutritional status and life style, may help to identify those factors that predispose to decreases in organ function and impairment of metabolic functions. A major strength of the NMAPS relates to our ability to examine age related changes that we have previously detected by more in-depth followup studies as well as the implementation of new research techniques. Following are just a few examples: 1 - How do changes in dietary intake relate to changes in body composition? As will be described later, we have incorporated a number of specific methodologies to assess body composition. 2 - Can the increased incidence of falls in the elderly be explained by decreases in muscle mass and or poor dietary habits? Also, what are the long-term health consequences for elderly people who fall frequently?.
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We thank Mette Lindell for skilful technical assistance and Dr R. A. Harris for critically reading the manuscript. Supporting grants were given by the Swedish Medical Research Council, the.
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