For the past decade lutein and zeaxanthin have become staple products for those concerned about eye health after a 1994 NIH study found that they may reduce the risk of Age-Related Macular Degeneration AMD ; .5 A new randomized, double-blind, placebo-controlled, multi-center study published in the Journal of Skin Pharmacology and Physiology found that lutein and zeaxanthin may also help protect the skin from damage caused by the sun's ultraviolet UV ; radiation. 6 Both of these antioxidants, lutein and zeaxanthin, naturally occur in the skin and are important to five primary skin physiology parameters: surface lipids, hydration, photoprotective activity, skin elasticity and skin lipid peroxidation. In order to test the effects of supplementing lutein and zeaxanthin, the researchers selected 120 healthy female volunteers from varying ethnic backgrounds with varying skin types. The volunteers had an average age of 35 years. They were given either placebos or lutein and zeaxanthin orally, topically, or both orally and topically in combination, such that the four test groups were created: 1. oral supplement and a liquid topical, both containing lutein and zeaxanthin; 2. oral supplement of lutein and zeaxanthin and a topical placebo; 3. oral placebo and a topical containing lutein and zeaxanthin; and 4. an oral placebo plus topical placebo. The researchers then exposed the volunteers skin to ultraviolet radiation and measured the results using several different parameters. All the volunteers who received one of the lutein and zeaxanthin treatments showed significantly less "sunburn" than those who received both placebos. The researchers reported, "the topical provides a two-fold increase in this activity in just two weeks, the oral [lutein and zeaxanthin supplement] more than a four-fold increase, and the combined [topical and oral supplement] a sixfold increase in photoprotective activity compared to the placebo." There was also an increase in the surface lipids, skin hydration, and skin elasticity. Most notably surface lipids increased by 63 percent among those who received both the topical and oral supplement, 46 percent among those who received the oral supplement only and 23 percent among the topical only. These results further demonstrate the impact oral supplementation can have on the outward appearance of skin. Optim-Eyes High-Potency Vision Support Formula contains both Lutein and Zeaxanthin, learn more about how these two carotenoids may be beneficial to your eyes as well as your skin at our website.
1. Erectile dysfunction is associated with risk factors for cardiovascular disease. 2. Phosphodiesterase-5 inhibitors are contraindicated in patients taking nitrates. 3. Phosphodiesterase-5 inhibitors are contraindicated in patients taking anti-hypertensive drugs. 4. Long term use of phosphodiesterase-5 inhibitors in patients with coronary heart disease is associated with more myocardial infarction and deaths. 5. Cardiac assessment is mandatory before starting phosphodiesterase-5 inhibitors for erectile dysfunction. Answers: 1. True. Erectile dysfunction is associated with risk factors for cardiovascular disease including lipid abnormalities, HT, smoking, DM, obesity and lack of physical activity. This may be related to the fact that endothelial dysfunction and atherosclerosis are systemic disorders. Risk factors for cardiovascular disease affect vascular supplies to corpora, for example, aspirin.
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Narcotics, " "other and unspecified narcotics, " and "other and unspecified drugs, medicaments, and biological substances" accounted for approximately half of all the documented substances associated with unintentional and undetermined poisoning deaths.
From the * Anesthesia Department, H3580, Stanford University Medical Center, Stanford, CA 94305-5115 and California Ear Institute at Stanford, 801 Welch Road, Palo Alto, CA 94304. Address correspondence to: Dr. John G. Brock-Utne, Anesthesia Department, H3580, Stanford University Medical Center, Stanford, CA 94305-5115. Accepted for publication 7th March, 1996 and telmisartan.
Dr. A.K. Gupta Indian Council of Medical Research New Delhi Dr. A.K. Gupta Indian Council Of Medical Research New Delhi Dr. A.M.Majumdar Botany Group Agharkar Research Institute Pune Dr. R.H.Singh Institute of Medical Sciences Banaras Hindu University Varanasi.
Tegretol ; , clonazepam Klonopin ; , gabapentin Neurontin ; , and lamotrigine Lamictal ; have also shown some success in treating PN pain. Side effects may include sedation, gastrointestinal upset, skin rash, and liver dysfunction. David M. Simpson, MD, and colleagues from Mount Sinai Medical Center in New York City and Johns Hopkins University in Baltimore reported in the June 13, 2000 issue of Neurology that lamotrigine significantly reduced neuropathic pain in a small, 14-week study of people with HIV AIDS-related DSP; a larger study is underway. Another medication that has been used to relieve neuropathic pain is the heart arrhythmia drug mexiletine Mxitil ; . Studies in diabetics and people with HIV AIDS-related neuropathy have yielded mixed results. An electrocardiogram EKG ; heart rhythm test should be done before a person is started on mexiletine. For severe neuropathic pain, narcotic analgesics a class of drugs derived from the opium poppy ; may be necessary. These include codeine, hydrocodone, hydromorphone, methadone, morphine, oxycodone, and the fentanyl transdermal patch Durgesic ; . Of these, Dr. McArthur recommends methadone, sustained-release morphine, and the fentanyl patch. Several weeks may pass before improvement is apparent. Under-treatment of chronic pain is common in the U.S. due to strict regulations on the use of narcotic drugs and fears that people will become addicted. However, many experts assert that addiction is unlikely when narcotics are used to treat pain. People with severe neuropathic pain may benefit from working with a pain management specialist. Psychotropic affecting psychological or mental functioning or behavior ; and narcotic drugs may interfere with antiretroviral medications, potentially leading to suboptimal dosing or intensified side effects. People with HIV AIDS-related PN should work with an experienced medical practitioner and make sure that every provider they see knows about all the drugs they are taking and minipress.
Secondary prevention early detection ; alerts fired 313 times, identifying 106 cases in which the physician agreed that action was required to evaluate or treat a possible ongoing ADE positive predictive value of 34% ; Table 3 ; . Twentyseven 25% ; of these were previously unrecognized. The most common detection alert firings were for possible pseudomembranous colitis and drug nephrotoxicity. The most common reasons for falsepositive primary prevention alerts were 1 ; importance of the radiocontrast media study was felt to outweigh the risk of nephrotoxicity n 81 ; , 2 ; disagreement that renal drug clearance was inadequate n 26 ; , and 3 ; planned shortterm or as-needed-only use of medications n 20 ; . For secondary prevention alerts, the most common cause for a false-positive alert was the determination that the observed complication was not drug related n 127 ; . Incidentally, true-positive alerts were associated with appropriate reductions in drug dosages in 135 patients. Eightyfour of these were previously unrecognized, and resulted in a savings of 254 drug doses 146 doses of antibiotics and 108 doses of nonantibiotic medications ; . The mean time spent by pharmacists evaluating each alert was 15.9 minutes SD, 12.8 minutes; range, 0-180 minutes ; . COMMENT Our system detected opportunities to reduce ADE-related injury at a rate of 64 per 1000 patient admissions. Previous measures of this rate are not available for comparison because this is the first study to prospectively evaluate a computer support system with real-time intervention for reducing injury from a broad range of ADEs. However, previous noninterventional studies have quantified the rate of opportunities to prevent ADEs. Leape and colleagues13 combined preventable ADEs and potential ADEs medication errors with the potential to cause ADEs ; to determine the total number of preventable events. A rate of 69 per 1000 patient admissions can be calculated from their reported data, 3, 13 which is similar to the rate in our study. Others have reported preventable event rates of 106 per 1000 admissions15 and 117 per 1000 admissions.7 Although we would strive to develop a system to circumvent all such preventable events, our set of alerts represents only a subset, and probably includes events that would not be classified as preventable or potential ADEs by other researchers. Nevertheless, several examples in which our preventive intervention failed to illustrate the serious potential conseJAMA, October 21, 1998--Vol 280, No. 15.
I recognize that there are many potentially destructive decisions I face every day and commit to you that I will do everything in my power to avoid making decisions that will jeopardize my health, my safety and overall well-being, or your trust in me. I understand the dangers associated with the use of alcohol and drugs and the destructive behaviors often associated with impairment and prazosin.
This booklet was produced by ORYGEN Youth Health to promote awareness of the benefits of early intervention on the long and short term health of young people with a mental illness. To find out about early intervention programs in your area, or to obtain extra copies of this booklet, contact the Early Intervention Worker at the Area Mental Health Service for your region, for example, prednisone.
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Department of Pharmacology K.H., M.S., J.S.P., J.S., S.C. ; , University of Copenhagen, Copenhagen, Denmark and Institute of Pathology N.M. ; , Randers Centralsygehus, Randers, Denmark Accepted for publication October 21, 1996.
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