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Altogether 13 parties filed oppositions against this patent before the December 1998 nine-month deadline, including Vivus, Schering-Plough Corporation, E Merck, OrthoMcNeil, Bayer and BMS in addition to the plaintiff, Lilly ICOS. A paper by Korenman & Viosca from Journal of the American Geriatrics Society 41: 363-366 ; entitled "Treatment of Vasculogenic Sexual Dysfunction with Pentoxifylline", published in April 1993, was cited as a key anticipatory reference while several other prior publications were quoted to support an obviousness objection. Lilly and ICOS have a special interest in this subject because IC-351, a PDE V inhibitor obtained in 1997 from Glaxo, is now in phase III trials for erectile dysfunction. Indeed a case from Lilly ICOS this week claiming unit dose forms of cGMP PDE inhibitors may refer to this very compound. 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