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Determination of the functional integrity of skin autonomous vascular regulation with laser Doppler technique G Szabad, 1 D Paprika, 2 L Kemeny, 1 A Dobozy1 and L Rudas2 1 Department of Dermatology and Allergology, Medical University of Szeged, Szeged, Csongrad, Hungary and 2 Department of Medical Intensive Care Unit, Medical University of Szeged, Szeged, Csongrad, Hungary Local and systemic regulatory mechanisms are responsible for maintaining proper skin blood supply. Failure of the skin autonomous vascular regulation poses severe problems in diseases like lymphoedema, diabetes mellitus, leg ulcers, Raynaud syndrome, etc. Determination of the integrity of cutaneous autonomous regulation of blood supply could be an important prognostic factor in the treatment of these diseases. We aimed to develop a non-invasive method for monitoring the integrity of skin autonomous vascular regulation. First we used baroreflexes under physiological conditions to initiate changes in skin blood flow. After this we used bretylium locally to neutralize sympathetic activity by presynaptically blocking noradrenalin release. Servo-photopletysmography was used to monitor haemodynamic changes, while laser Doppler technique was used for measurement of skin blood flow. Without bretylium treatment cutaneous vascular resistance showed a significant, threefold increase in the hypotonic phase of the baroreflex maneuver. Bretylium treatment completely inhibited this increase. Our data indicate that baroreflex stimulus results in vasoconstriction of skin arterioles and this vasoconstriction is the result of sympathetic efferent activity. We propose that monitoring of cutaneous vascular resistance over bretylium treated and non-treated skin areas is a convenient and non-invasive method to determine the functional integrity of skin autonomous regulation of blood supply.
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ROSULA NS . 43 RYNA-12X . 69 RYTHMOL SR . 36 SAIZEN . 56 SALAGEN . 28 sal-amide acetaminophn ptlox . 8 salsalate . 8 SALURON. 36 SANCTURA . 49 SANDOSTATIN . 56 SANTYL . 43 SEASONALE . 56 selegiline hcl . 22 selenium sulfide . 43 SEL-PEN. 43 SELSEB . 43 SEMPREX-D. 69 SENSIPAR . 57 SEREVENT DISKUS . 69 SEROMYCIN . 19 SEROQUEL . 23, 28 SEROSTIM . 56 silver nitrate. 43 silver sulfadiazine. 43 SIMETYL. 28, 47 SINGULAIR. 70 SKELAXIN . 71 SKELID . 56 sod chloride nahco3 kcl peg's . 47 sod sulf sod nahco3 kcl peg's . 47 sod potass k cit sodium cit ca . 49 sodium flouride tabs . 38, 73 sodium phos, m-basic-dbasic. 73 sodium polystyrene sulfonate . 73 SOLARAZE . 43 SOMATROPIN . 56 SOMAVERT . 57 SORIATANE . 43 sotalol hcl . 28, 36 and tretinoin.
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Aseptic thrombophlebitis of peripheral veins due to intravenous catheters and catheter-related bacteraemia, which both usually respond to removal of the intravascular device, are common conditions [1]. Septic or suppurative thrombophlebitis of large proximal veins, a condition characterised by microabscess formation within the thrombotic vein and repeated bacterial embolisation into the circulation, is a severe systemic disease which has received little attention in the literature [24]. In intravenous drug users IVDU ; , skin or subcutaneous abscesses and suppurative thrombophlebitis of small veins are well-recognised complications after unsterile and usually unsucNo financial support to declare and rifater.
TOP 25 DRUGS BASED ON TOTAL CLAIMS COST FROM 07 01 06-07 % Total Paid Rx Claims 270.47 0.78% 271.14 0.00% 263.75 0.37% 84.45 0.00% 30, 002.54 0.00% 126.92 0.44% 290.99 Drug AHFS Therapeutic Class RISPERDAL ANTIPSYCHOTIC AGENTS SEROQUEL ANTIPSYCHOTIC AGENTS SINGULAIR LEUKOTRIENE MODIFIERS ABILIFY ANTIPSYCHOTIC AGENTS ZYPREXA ANTIPSYCHOTIC AGENTS PREVACID PROTON-PUMP INHIBITORS ZYRTEC SECOND GENERATION ANTIHISTAMINES FEIBA VH IMMUNO HEMOSTATICS TOPAMAX ANTICONVULSANTS, MISCELLANEOUS OMNICEF CEPHALOSPORINS ADDERALL XR AMPHETAMINES ADVAIR DISKUS BETA-ADRENERGIC AGONISTS CONCERTA AMPHETAMINES PULMICORT ADRENALS GABAPENTIN ANTICONVULSANTS, MISCELLANEOUS EFFEXOR XR ANTIDEPRESSANTS TRILEPTAL ANTICONVULSANTS, MISCELLANEOUS LIPITOR HMG-COA REDUCTASE INHIBITORS LAMICTAL ANTICONVULSANTS, MISCELLANEOUS HELIXATE FS HEMOSTATICS ADVATE HEMOSTATICS PLAVIX PLATELET-AGGREGATION INHIBITORS GEODON ANTIPSYCHOTIC AGENTS STRATTERA CENTRAL NERVOUS SYSTEM AGENTS, MISC. AMOX TR-POTASSIUM CL PENICILLINS TOTAL TOP 25 Total Rx Claims From 07 01 06-07 Health Information Designs, Inc.
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