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The Outlook for Cardiovascular Risk Factors: Epidemiology, market and pipeline analysis CHAPTER 1: DEFINING CARDIOVASCULAR RISK What is a risk factor? How do risk factors contribute to cardiovascular disease? Ethics and practicalities of preventive therapy Impact of an aging population CHAPTER 2: HYPERTENSION Classification of hypertension Epidemiology Drug therapy Impact of ALLHAT study on anti-hypertensive therapy Market analysis Norvasc amlodipine ; Cozaar Hyzaar losartan losartan HCTZ ; Diovan Co-Diovan valsartan valsartan HCTZ ; Outlook for the hypertension market Unmet needs Pipeline analysis - Benicar olmesartan ; - Inspra eplerenone ; - Vanlev omapatrilat ; - ALT-711 CHAPTER 3: DYSLIPIDEMIA Overview of dyslipidemia Which markers are the best indicators of cardiovascular risk? Epidemiology Drug therapy Statins Fibrates Bile acid sequestrants inhibitors Nicotinic acid derivatives Fish oil derivatives Market analysis Outlook for the dyslipidemia market Unmet needs Pipeline analysis Livalo pitavastatin ; Caduet atorvastatin + amlodipine ; CHAPTER 4: DIABETES Overview of diabetes Pathophysiology and etiology Epidemiology Drug therapy Market analysis Outlook for the diabetes market Unmet needs - Drug delivery - Efficacy - Side effects - Awareness and education - Glucose monitoring - Pipeline analysis CHAPTER 5: OBESITY Overview of obesity Pathophysiology and etiology Epidemiology Drug therapy Market analysis Outlook for the obesity market Improving long-term drug safety Pipeline analysis - Topaamax topiramate ; - Axokine - P57 CHAPTER 6: SMOKING CESSATION Overview of smoking cessation Pathophysiology Epidemiology Drug therapy Market analysis Outlook for the smoking cessation market Unmet needs Pipeline analysis - Zyban XL bupropion ; - Rimonabant - TA-NIC - NicVAX and topiramate.
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Keywords Session C Acceptance, composting toilets, improvement, maintenance, peri -urban areas, public use Abstract Two projects are reported, using composting toilets as single solution for treating human was te. An ecological settlement in Bielefeld with 270 inhabitants now, was started in 1994. More than 100 flats up to four stories high and a public Kindergarden were established since then. Problems with building codes and planning details are described as well as the different experiences in maintaining the biological process. The results after 8 years of practise led into different product improvements. In 1995, an old villa in the middle of the town of Rostock was reconstructed for use as offices, shops and a restaurant, supplied with composting toilets. For five years research was done together with the University of Rostock, proving health aspects in use and experiences in the maintenance of the system. Beside the realization of product improvements, the training of the staff, who are responsible for the function of the system, was determining for a successful process and the high motivation of the project members. Composting toilets in the ecological settlement Bielefeld -Waldquelle Pioneer projects in Germany In Germany composting toilets Clivus Multrum and similar systems ; are offered since 1980 and are mainly installed in family houses. In 1986, the first ecological settlement was established to demonstrate decentralized solutions using composting toile ts and constructed wetlands for cleaning greywater Hamburg-Allermhe ; . Others followed in Kiel, Berlin, Bielefeld and Hamburg-Braamfeld, while the ecological settlement in Bielefeld even seems to be the largest one in Europe 70 containers ; . At the moment there are about 500 composting toilet systems mainly TerraNova systems ; installed. Concept and realization In 1988, a group of ecologically interested families and the architectural office Bltmann started planning a peri-urban settlement in Bielefeld-Quelle. Different social groups should participate and additionally the consequent realization of ecological standards be performed. From 1994 until 1999 family houses, multistory houses and a public Kindergarden, planned by different architectural offices, were established, all provided with composting toilets. Greywater should be treated by constructed wetlands, but are not built yet because of the lack of financial means. Greywater is therefore connected to the sewer system up to now. One characteristic o f the settlement is the installation of composting toilets for houses up to four stories, which seems to be the first project of this kind in Europe.
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