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As bolus or mealtime insulin. Mealtime insulin doses are adjusted based on the amount of carbohydrate in the meal. An insulin-to-carbohydrate ratio can be established for an individual that will guide decisions on the amount of mealtime insulin to inject. Basal or background insulin dose is that amount of insulin required in the postabsorptive state to restrain endogenous glucose output primarily from the liver. Basal insulin also limits lipolysis and excess flux of free fatty acids to the liver. The type and timing of insulin regimens should be individualized, based on eating and exercise habits and blood glucose concentrations. For normal-weight persons with type 1 diabetes, the required insulin dosage is about 0.5 to 1.0 U per kilogram of body weight per day. About 50% of the total daily insulin dose is used to provide for basal or background insulin needs such as NPH or glargine ; . The remainder rapid-acting insulins, such lispro or aspart ; is divided among the meals either proportionate to the carbohydrate content or by giving about 1.0 to 1.5 U insulin per 10 g carbohydrate consumed. The larger amount is usually needed to cover breakfast carbohydrate as a result of the presence in the morning of higher levels of counterregulatory hormones Rabasa-Lhoret et al, 1999 ; . Persons with type 2 diabetes may require insulin doses in the range of 0.5 to 1.2 U per kilogram of body weight daily. Large doses, even 1.5 U kg of.

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Oxidizing 4 -N-desmethyl-2-hydroxymethyl OLZ with chromium trioxide. The positive-ion spectrum of this metabolite yielded an MH ion of m z 329. The product-ion spectrum fig. 9 ; showed diagnostic losses of 17 Da loss of NH3 from the piperazine ring ; and 43 Da loss of CH2AN--CH3 from the piperazine ring ; to give m z 312 and 286, respectively. The presence of an ion at m z CH2ACH--NH-- CH2--CH2 ; also indicated that this compound was a demethylated analog of OLZ. MS analysis of the isolated metabolite after diazomethane derivatization afforded a protonated molecular ion of m z 343, providing additional evidence for an N-desmethyl-2-carboxy OLZ structure for this metabolite. 2-Carboxy OLZ--The isolated metabolite peak 2, fig. 6 ; had the same retention time as a sample of authentic 2-carboxy OLZ. Product ion spectrum precursor m z 343 ; produced fragment ions at m z 312 loss of CH3NH2 ; , 286 loss of CH2ACH--NH--CH3 ; , 243 loss of the methyl piperazinyl moiety ; , and 84 [CH2ACH--N CH3 ; -- CH2--CH2 ]. The product ion spectrum was identical to that obtained from the authentic standard. 2-Hydroxymethyl OLZ--The metabolite eluting as peak 1 in fig. 5 had the same HPLC retention time as the synthetic standard of. POND ACTIL SINUSAID SUFED MEDIFED ACTIPLEX ACTIFED DIPHERELINE P.R DIPHERELINE P.R ACTICHLOR POSE-AID STERI-TAB MYDRIACYL SPASMO-LYT TUBERCULIN TINE TE TUBERCULIN TINE TE TUBERCULIN TINE TE MIST TUSSIS MIST TUSSIS MIST TUSSIS MIST TUSSIS MIST TUSSIS MIST TUSSIS JAWKEPTA TACORCIN TROCACIN TRONEO BIO-QUINONE Q-10 RESCULA UREA CREAM UREA CREAM URSOLIN URSOFALK INFANRIX IMMUCYST DTCOQ DTP PENTAXIM TETRACT-HIB INFANRIX-HEXA. Title Source Very early statin treatment improves outcomes in acute coronary syndrome? J Cardiol 2004; 94: 1166-1168 Reuters Health News Link - Registration required, because d urso design.
Cheers: Two important points: Moscow's best burgers and best breakfasts. eXile staffers agree: late night plate of nachos are vastly preferable to clubbing. The chili may not be world famous but it is yummilicious and Moscow's best. Hot damn them burgers ROCK! Because Starlite continues to be the ONLY place in Moscow that really knows breakfast, we got rid of the failed "Breakfast" section in our guide. Mongolicious omelets that even tames the violent temper of Morris U. Snideman, Esq. Stomach-expanding breakfast burritos makes good alternative. Sandwiches put the `take' in shitake! Recent tasting of the Asian Chicken burger proved that healthy can be tasty. We can't lie: we often come twice a day. Moscow's top 24hour eatery. Milkshakes huge again, and orgasmic. Try the coffeechocolate-oreo mix. Jeers: Expat hell. We go here so much our palms are growing hair. M: Diner 1: Mayakovskaya Diner 2: Oktyabrskaya Phone: #1: 290 - 9638; #2: 959-8919 Address: #1: Sadovaya Bolshaya ul. 16; #2: Ul Korovy val. 9 Hours: 24 hours duce a pan-Asian delight at reasonable prices. In short, we highly recommend the Kaiso salad and tofu in peanut sauce 250R ; , raise two chopsticks high for the massive wonton soup with shrimp and crab meat 235 ; , a tops in Moscow. Service, cheerful interior all a plus. When the weather warms, the summer patio is ready. Excellent place to take a date. Jeers: We'll let you know when we have one. M: Okhotny Ryad Phone: 923-2422, 961-3441 Address: Kamergersky per. 5 6 Hours: noon - 23.00 M: Kropotkinskaya hone: 202-0445 Address: Ostozhenko 12 1 Hours: 11.00 - midnite.

One-way ANOVA was performed to determine whether the mean values for OTC purchases at the two locations were significantly different across demographic characteristics. The frequency of OTC purchases in convenience stores Table 5.7 ; and pharmacies Table 5.8 ; were dependent variables, while gender, education level, household income, age groups, and parent guardian status were independent variables. Table 5.7 indicates there were significant differences in the number of OTC purchases in convenience stores across age groups. Post-hoc analysis using the Scheffe test revealed that respondents aged 75 to 84 years purchased OTC medicines in convenience stores significantly more often 1.66 times ; than those in other groups: 25 to 34 years 0.88 times 45 to 54 years 0.89 times 55 to 64 years 0.89 times 65 to 74 years 1.05 times ; and 35-44 years 1.17 times and ursodiol. Studies have shown that people with mental illnesses, when treated, are no more violent than the rest of the population. But, these studies have also demonstrated that lack of treatment or inappropriate treatment does increase the risk of violence. For example, a three site study recently funded by theMacArthur Foundation on violence and mental illness demonstrated that 17.4 % of psychiatric patients studied were violent in the 10 week period prior to hospitalization, during which time they generally were not being treated, compared to an average of 8.9% for the five 10-week periods after hospitalization during which time most individuals were being treated. Henry Steadman, Edward Mulvey, John Monahan, et al, "Violence by People Discharged from Acute Psychiatric Inpatient Facilities and by Others in the Same Neighborhoods", Archives of General Psychiatry 55: 393-401, 1998. See, also, Marvin Swartz, John Swanson, Virginia Hiday, et al, "Violence and Severe Mental Illness, American Journal of Psychiatry, 155: 226231, 1998; " substance abuse problems, medication noncompliance, and low insight into illness operate together to increase violence risk ; ." Daniel Colwell's increasingly bizarre behaviors over a period of ten years demonstrated that he needed more than periodic injections of medication to maintain his psychiatric stability. At Southwestern State Hospital in Thomasville, where he was sent in August 1989 after the television station incident, the admitting physician observed Mr. Colwell as "paranoid, hyper verbal, suffering from religious delusions, threatening, agitated, sexually preoccupied, with loose associations." Appellant's Brief, at 41. In October, 1989, he was admitted on an emergency physician's certificate who observed, inter alia, "overt homicidal ideations, secondary to admitted auditory hallucinations . with some violent potential." Id at 43. In 1992, the psychiatrist who treated Colwell in. En les classes de didctica de la msica de segon curs, es procura que els alumnes tinguin una aproximaci terico-prctica als principals blocs de continguts que cal treballar a l'escola, que els indueixi a reflexionar sobre aquests i sobre els processos d'ensenyament-aprenentage en l'mbit musical. Aix mateix, es procura que vivencin activitats prpies de cada un dels blocs, que coneguin recursos didctics i materials adequats per a les diverses activitats, etc. En general, en aquesta etapa inicial, les explicacions de caire ms teric i l'exemplificaci prctica corren a crrec del professor de l'assignatura, propiciant des del primer moment la participaci de l'alumnat, al qual s'anima a plantejar qestions, a expressar opinions i punts de vista, a formular hiptesis i deduccions relacionades amb all que s'exposa. Especialment valuoses sn les and valproic.

RESULTS After rising steadily for approximately 7 years, methamphetamine-related hospital admissions in California began a visually striking decline in November 1989, the month methamphetamine precursors in bulk powder form were regulated Fig. 1 ; . The decline continued for approximately 2 years. In 1992, admissions in California resurged and surpassed their peak preintervention counts, and continued rising throughout much of 1995 Fig. 2 ; . Admissions in Arizona and Nevada also rose sharply during the same period. In August 1995, the month that single ingredient ephedrine products were regulated, admissions in all three states dropped sharply for a period of approximately 6 months. In 1996, admissions resurged in all three states. In October 1997, however, the pseudoephedrine product regulation was implemented, and admissions began another sharp decline in all three states, this one lasting approximately 1 year. In late 1998, admissions started.
Are required to establish an irreducible set, and often the Laplacian and isophote are used. Table 3.1. First and Second order rotational invariants and valacyclovir. Nonabsorbed ursodiol passes into the colon where it is mostly 7-dehydroxylated to lithocholic acid. South on animal health issues. The administrations have traditionally shared information at local and national levels on disease control and surveillance issues and have worked together to combat illegal movements of animals and animal products. During the Foot and Mouth emergency of 2001 the co-operation and consultation at official, Ministerial and political levels was vital. The establishment of the North South Ministerial Council NSMC ; offered an opportunity to build on existing co-operation arrangements and provided a framework for the development of an all-island animal health policy. The main objectives of the Council are to foster co-operation and to devise a common, unified animal health strategy for the island as a whole. This involves the convergence of animal health policies and the development of joint strategies for dealing with animal diseases. The ultimate objectives of an allisland animal health policy are to establish a common import regime and equivalent internal arrangements with a view to achieving free movement of animals and animal products within the island. The programme of work, mandated by the NSMC, is being progressed by nine working groups at official level. The remit of these groups includes TB and Brucellosis, TSEs BSE and Scrapie ; , veterinary medicines, other Zoonoses and animal diseases, disease surveillance, animal welfare, import and export of live animals and animal products, animal identification, traceability and cross-border aspects of fraud. These working groups meet regularly and their work has focused on three main themes: Common or equivalent controls at points of entry to the island; Convergence of internal animal health policies; and Development of joint strategies for the control of animal disease. The main achievements to date are the development of a co-ordinated and complementary approach towards import policies and portal controls at points of entry to the island, the convergence of policies in regard to animal identification and Scrapie and the strengthening of coordination and co-operation between both administrations on a variety of issues such as T.B, Brucellosis, FMD, BSE, Avian Influenza, crossborder fraud, etc. These groups continue to report progress in exchange of information and in implementation of initiatives aimed at policy convergence and the development of a common unified strategy for the island as a whole. The Farm Animal Welfare Advisory Council includes representation from the Department of Agriculture and Rural Development, DARD ; . A representative from DARD also attends the Avian Influenza Advisory Group and ativan.
46 alzheimer beta a4-amyloid protein precursor in immunocompetent cells.
6. Neuropathological effects of other treatments 6.1. Electroconvulsive therapy A comprehensive recent review concluded that ECT has no demonstrable structural effects Devenand et al., 1994. Whilst reassuring, there are minor caveats. The presence of subtle changes in neurons and synapses following ECT akin to those reported in schizophrenia has not been inves tigated in human brain; in rats administered electroconvulsive shocks, alterations in synaptic proteins Jorgensen and Bolwig, 1979 and enhanced expression of the astrocytic marker glial fibrillary acidic protein GFAP; Orzi et al., 1990; Steward, 1994 and of the dendritic microtubule associated protein MAP-2 Pei et al., 1998 have been reported, as well as hippocampal neurotoxic ity Enns et al., 1996. Though the applicability of the animal experiments to the clinical situation is questionable, since a higher stimulus intensity is used and only short-term effects have been mea sured see Devenand et al., 1994, it would be prudent to bear the data in mind when studying the brain of a person who had received ECT in the weeks prior to death. 6.2. Lithiwn Case reports Schneider and Mirra, 1994 and studies in monkeys Akai et al., 1977 show that fatal lithium overdose is associated with a variety of findings in keeping with an acute neurotoxicity. Whether long-term treatment with lithium at thera peutic levels produces neuropathological effects is much less clear, since there have been no such studies of humans or monkeys. In rats, lithium administered for 30 weeks at serum levels of 0.50.8 mmol l with or without concurrent haloperi Experimentally, antidepressants have been reported to have subtle histological effects Smialowska et al., 1988; Nakamura, 1990; Kitayama et al., 1997 and measurements in human cerebrospinal fluid suggest that they may interfere with 13-amyloid precursor protein meta bolism Clarke et al., 1993. There are no relevant neuropathological data. 6.4. Historical treatments Amongst the subjects included in post-mortem studies are elderly patients who were subjected to insulin coma therapy or leucotomy. Although the impact of these interventions is likely to be less than that of antipsychotics, if only because a smaller proportion of the subjects have received them, they are still potential neuropathological confounders Roizin, 1972; Pakkenberg, 1989 and bextra. A review of vitamin d the story of vitamin d begins when a vitamin d precursor is eaten. Let us know what you work out regarding your medication, phaedrus and cialis.
Until recently, efforts at the federal level to stem the growing tide of methamphetamine production and use have focused largely on controlling the diversion of large amounts of precursor chemicals to super labs. Notable pieces of federal legislation with which pharmacists should be familiar are: s The Chemical Diversion and Trafficking Act of 1988. s The Comprehensive Methamphetamine Control Act of 1996. s The Methamphetamine Anti-Proliferation Act of 2000.
Two-dimensional gel electrophoresis of acidic and basic [35S]methionine-labeled polypeptides derived from primary cultures of human retinal-pigment epithelial cells revealed about 850 proteins. By co-electrophoresis with highly purified, evolutionally conserved proteins, a-actinin, calmodulin, cytosol retinal-binding protein, a- and f3-tubulin, and vinculin mass: 130 000 Da ; were tentatively identified in the fluorograms. Quantification of 100 of the excised radioactive spots by liquid scintillation counting revealed an estimated overall gel gel and donor donor variation of 40% SEM, 21% ; , the latter for data on three to four donors 57 to 81 years old. Therefore, for a difference from normal to be significant p O.01 ; , it would, on average, have to exceed 88% of the control mean for that protein. Putative glycoproteins were independently radiolabeled, with tritiated sugars as precursors. Glucosamine was incorporated most rapidly and with the highest specific activity. It labeled about 170 polypeptides. Fucose and N-acetylmannosamine, respectively, labeled 74 and 27 polypeptides. The glycoprotein label was maximal in about 16 very acidic proteins with apparent molecular masses between 50 000 and 150 000 Da. Parallel use of both a sugar and an amino acid label facilitates identification of proteins in two-dimensional gels. AddItIonal Keyphrases and danazol.
Qu debe hacer con esta informacin? Si le preocupan algunos de los efectos de las hormonas que usted est tomando o piensa tomar, puede consultar con un endocrinlogo, que es un experto en terapia hormonal. Se recomiendan autoexmenes mensuales y exmenes anuales hechos por su mdico. Debe hacerse una mamografa anual si tiene 40 aos o ms, aun si no tiene ningn sntoma. Tambin, si tiene menos de 40 aos y su familia tiene antecedentes de cncer en el seno o en los ovarios debera de hacerse una mamografa. Recursos.

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Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States] - GYNECOL. ONCOL. 2006 103 2 ; - summ in ENGL Objective.: From analysis of pre-cancer ovarian tissues obtained from prophylactic oophorectomies, several studies reported the increased ovarian morphological changes in high-risk ovaries, but whether these morphological changes are associated with BRCA1 BRCA2 genotypes or are cancer precursors is controversial. Here, we have investigated a recent collection of ovaries from prophylactic oophorectomies and control ovaries from surgeries due to other non-ovarian-related cancer or non-neoplastic diseases to determine if ovarian morphological changes relate to BRCA1 2 genotypes or reproductive history. Methods.: We assembled a panel of archived ovarian tissues: 52 ovarian tissue blocks were from prophylactic oophorectomies of a high-risk HR ; population; 66 ovaries were from surgeries due to non-ovarian-related diseases, referred to as normal-risk NR ; group. The morphology of ovarian tissues was examined, and morphological changes including papillomatosis, invaginations, inclusion cysts, and epithelial stratification were assessed in a blinded fashion. Results.: No statistically significant difference in frequency of these histolopathologic features was found between HR and NR groups. However, inclusion cysts and deep invaginations were found much more commonly in women age 45-54 of either HR or NR groups. Conclusions.: This study suggests that no significant increase in the presence of non-neoplastic ovarian morphological changes is associated with BRCA1 BRCA2 mutations. Rather, the frequency of these histological features, especially inclusion cysts, may associate with age or menopausal status. We propose that ovulatory and perimenopausal gonadotropin stimulation produces ovarian morphological changes, and these histological features may promote the transformation of genetically compromised epithelial cells in the development of ovarian cancer. 2006 Elsevier Inc. All rights reserved. 665. What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma EOC ; ? Chi D.S., Eisenhauer E.L., Lang J. et al. [D.S. Chi, Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, MRI-1026, New York, NY 10021, United States] - GYNECOL. ONCOL. 2006 103 2 ; - summ in ENGL Objective.: Recent studies have suggested that the definition of optimal cytoreduction for advanced EOC should be changed from the current Gynecologic Oncology Group threshold of 1 cm residual disease to no gross residual disease owing to improved survival of patients pts ; rendered macroscopically disease-free. The objective of this study was to analyze survival rates at very specific residual disease diameters to determine the optimal goal of primary cytoreduction for bulky stage IIIC EOC. Methods.: A prospectively kept database was used to identify and review the records of all pts with Stage IIIC EOC who underwent primary cytoreductive surgery at our institution between January 1989 and December 2003. To analyze a homogeneous cohort of cases, we excluded pts with stage IIIC disease based on nodal metastasis alone without bulky abdominal tumor ; , fallopian tube or primary peritoneal carcinomas, and borderline tumors. Standard statistical analyses were utilized. Results.: The study cohort included 465 pts. The median age was 60 years range, 25-87 ; , and the median follow-up was 38 months range, 1-199 ; . Univariate and multivariate analyses, which included various prognostic factors, identified amount of residual disease as a significant prognostic factor P 0.001 ; . Median overall survival in relation to the 5 residual disease categories was: no gross residual, 106 months; gross 0.5 cm, 66 months; 0.6-1.0 cm, 48 months; 1-2 cm, 33 months; 2 cm, 34 months. Statistical comparison between the 5 residual disease categories revealed 3 distinct groups with significantly different survival rates P 0.01 ; . These 3 groups were: 1 ; no gross residual; 2 ; gross 1 cm residual; and 3 ; 1 cm residual. Although the difference in survival did not reach statistical significance, within the gross 1 cm residual group, there was a trend toward improved survival in pts left with smaller volume, 0.5 cm residual compared with those with 0.6-1.0 cm residual P 0.06 ; . Conclusion.: Our data suggest that removal of all evidence of macroscopic disease is associated with prolonged survival and should be the goal of primary cytoreductive surgery. If complete gross resection is not feasible and darvon. Al., 1995; Porter et al., 1998 ; . This indole Nacetyl-5-methoxytryptamine ; is primarily synthesised and released by the pineal gland of vertebrates. The daily rhythm in circulating melatonin levels, with high levels occurring in the dark, is a well-known phenomenon Reiter, 1993 ; . Furthermore, melatonin displays annual fluctuations, which provide the organism with time-of-year information Reiter, 1993 ; . The role of melatonin in the mechanism controlling rhythmic adaptations to daily and seasonal cycles in fish is generally accepted for review: Kulczykowska, 2002 ; . Moreover, melatonin interacts with other hormones and thus adjusts fish to changes in environment Kulczykowska, 1995, 2002 ; . One of the most clearly defined endocrine changes during the parrsmolt transformation of anadromous salmonids is an increase in plasma levels of thyroid hormones Boeuf, 1993; Ebbesson et al., 2000 ; . Thyroxine T4 ; is the primary secretory product of the thyroid gland. T4 has little direct action, being mostly regarded as a precursor for triiodothyronine T3 ; , a biologically active form of the hormone Leatherland, 1994 ; . One of the best known examples of thyroid hormones effects is the initiation and regulation of amphibian metamorphosis Atkinson, 1981 ; . There is a large body of evidence that thyroid hormones play an important role in regulation of development, growth and reproduction in fish Power et al., 2001 ; . It is fully accepted that metamorphosis in flatfishes Pleuronectiformes ; is mediated by thyroid hormones Inui and Miwa, 1985; Schreiber, 2001 ; . Whether there is a case in the parrsmolt transformation in salmonids is still a matter of debate, because only few of the developmental changes that are considered to represent smoltification are induced by thyroid hormone administration Boeuf, 1993; Leatherland, 1994 ; . The aim of the present work was to determine if administration of exogenous T4 affects plasma melatonin in juvenile Atlantic salmon at early stages of parrsmolt transformation. 2. Materials and methods 2.1. Animals and experimental conditions Juvenile Atlantic salmon a little over 1-yearold; mass f30 g ; , from wild broodstock of the Dale anadromous strain Southwest Norway ; , were obtained in January 2001. The fish were kept in. Results are tabulated in table example 2 the procedure of example 1 was followed except that 75 grams of water and 20 grams of di secondary butyl ; peroxydicarbonate was used and deltasone and urso, for example, luca urso.
JA Lawson1, 2, DC Rennie1, A Senthilselvan2 1Institute of Agricultural Rural and Environmental Health, University of Saskatchewan, Saskatoon, Saskatchewan; 2Department of Public Health Sciences, University of Alberta, Edmonton, Alberta BACKGROUND AND PURPOSE: Factors associated with the development of wheeze in children is limited. We conducted studies in 2000 and 2003 in Estevan, Saskatchewan to examine respiratory conditions in. By ketoconazole in humans but fecal cholesterol elimination was inconsistently decreased because endogenous intestinal cholesterol flux mainly biliary cholesterol ; was also reduced 8, 9 ; . In HepG2 cell cultures, ketoconazole increased receptor-mediated binding, uptake, and degradation of LDL 12 ; . Accordingly, it can be hypothesized that inhibition of cholesterol absorption and synthesis will result in up-regulation of LDL receptor activity. This hypothesis was tested in the present study by performing kinetic analysis of total LDL apoB and of its dense subfraction in hypercholesterolemic patients before and during ketoconazole treatment. We were also interested in the serum levels of noncholesterol sterols, especially of lanosterols and their relationship to LDL metabolism and distribution between different lipoproteins during hypolipidemic treatment with ketoconazole. Additional information concerning possible changes in ACAT activity during ketoconazole treatment was studied by determining free and esterified levels of precursor sterols because methostenols are specific ACAT substrates and desyrel. FIGURE 1. Tamoxifen and raloxifene did not act as agonists to promote DC differentiation from BM precursors. BM cultures were grown for 7 days in DEF medium, then harvested and stained with mAbs specific for CD11b and CD11c. FACS analyses of cultures supplemented with 1 nM E2 plus DMSO A ; , the vehicle control V ; of ethanol only B ; , 200 nM tamoxifen Tam ; C ; , or 200 nM raloxifene Ral ; D ; are shown. Numbers indicate the percentage of total cells within the boxed region. Significant development of DC was observed only when E2 was added back to the medium. These data are representative of five independent experiments. Departments & services for patients research & trials education find a doctor find a specialist: make a referral online or call 1-800-789-penn patient education articles about the brain and nervous system penn today online current issue penn urgent care center at south street physician announcements archive of articles subscribe to the newsletter newsletter rss feed penn today online referral directory physician tools urgent patient transfer upcoming cmes urine test predicts alzheimer's disease march april 2003 researchers at penn have determined that a urine test can reliably detect free radical damage associated with mild cognitive impairment mci ; - a recognized precursor to alzheimer's disease ad.

Cenestin cenestin is a prescription or over-the-counter drug which is or once was ; approved in the united states and possibly in other countries. Function of phytoestrogens. Soy, other beans, clover, and alfafa contain isoflavone precursors, which are converted to genistein, daidzein, and equol by intestinal bacteria. Flax seeds, other seeds, legumes, whole grains, and some fruits and vegetables contain lignan precursors that can be converted to enterolactone and enteridiol by intestinal bacteria. The phytoestrogens can have estrogenic activity as potential dietary derived modulators with endocrine function. To date, studies have been small and lack statistical power, and these studies cannot be readily aggregated to increase the statistical power due to differences in their methodologies. In the systematic review by Kronenberg and Fugh-Berman, only 3 of the 12 randomized controlled trials found that soy phytoestrogen supplements or soy products reduced the frequency or severity of hot flashes. In one of the studies the decrease in hot flashes was accompanied by increases in 17 -estradiol and decreases in total and LDL cholesterol 27 ; . Flax seeds have been reported to have estrogenic, antiestrogenic, and steroid-like activity 22 ; . Although the phytoestrogen in soy is often used by women who are trying to control menopausal symptoms, a recent study found that 25 g of flax seed alters metabolism of estradiol in favor of 2-hydroxyestrone, which is less biologically active 41 ; . Theoretically, the metabolic shift could be accompanied by a reduction in menopausal symptoms. However, there are no published studies that have focused on the potential of flax seed in controlling menopausal symptoms. A soy beverage did not reduce the hot flash score frequency and severity ; to any greater extent than the placebo in a study involving women with breast cancer 42 ; . Red clover contains the phytoestrogen formononectin, biochanin A, daidzein, and genistein. Isoflavone and other supplements derived from red clover are readily available. The overall finding of research to date is that red clover and its related supplements are not better than placebo in controlling hot flashes. Promensil total isoflavone content 40 mg per tablet ; , which was not found to be beneficial in controlling menopausal symptoms in a study that tested the 40-mg dosage, was found to reduce moderate to severe symptoms at 80 mg per day 43 ; . Promensil was also not found to affect breast tissue density, unlike estrogen, which increases density, and tamoxifen, which reduces density. How the phytoestrogens interact with SERMs needs to be evaluated 44 ; . More research is also needed to address how commonly eaten foods that contain phytoestrogens fennel, celery, parsley, nuts, whole grains, apples and alfalfa ; affect menopausal symptoms as well as addressing the effects of supplements. 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