We thank Drs. Hiroshi Miyamoto, Cheng-Lung Hsu, Ni Jing, and Loretta Collins of Dr. Chang's laboratory for their helpful suggestions and discussion of the manuscript. Address all correspondence and requests for reprints to: Chawnshang Chang, Ph.D., Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642. E-mail: chang urmc.rochester The research described in this review was supported by the George Whipple Professor Endowment and National Institutes of Health Grants DK60905 and DK60948. Present address for C.A.H.: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North Seattle, Washington 98109.
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M, Magnotta VA, Knopp MV. MR microcirculation assessment in cervical cancer: correlations with histomorphological tumor markers and clinical outcome. J Magn Reson Imaging 1999; 10: 267276. Taylor JS, Tofts PS, Port R, et al. MR imaging of tumor microcirculation: promise for the new millennium. J Magn Reson Imaging 1999; 10: 903907. Andersen C, Jensen FT. Differences in blood-tumour-barrier leakage of human intracranial tumours: quantitative monitoring of vasogenic oedema and its response to glucocorticoid treatment. Acta Neurochir Vienna ; 1998; 140: 919 Griebel J, Mayr NA, De Vries A, et al. Assessment of tumor microcirculation: a new role of dynamic contrast MR imaging. J Magn Reson Imaging 1997; 7: 111 Rijpkema M, Kaanders JH, Joosten FB, Kogel AJ, Heerschap A. Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging 2001; 14: 457 Koh TS, Zeman V, Darko J, et al. The inclusion of capillary distribution in the adiabatic tissue homogeneity model of blood flow. Phys Med Biol 2001; 46: 1519 Kuhl CK, Mielcareck P, Klaschik S, et al. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 1999; 211: 101110. Brix G, Bahner ML, Hoffmann U, Horvath A, Schreiber W. Regional blood flow, capillary permeability, and compartmental volumes: measurement with dynamic CT--initial experience. Radiology 1999; 210: 269 Knopp MV, Weiss E, Sinn HP, et al. Pathophysiologic basis of contrast enhancement in breast tumors. J Magn Reson Imaging 1999; 10: 260 Port RE, Knopp MV, Hoffmann U, MilkerZabel S, Brix G. Multicomparmental analysis of gadolinium chelate kinetics: blood-tissue exchange in mammary tumors as monitored by dynamic MR imaging. J Magn Reson Imaging 1999; 10: 233 Barbier EL, Den Boer JA, Peters AR, Rozeboom AR, Sau J, Bonmartin A. A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images. J Magn Reson Imaging 1999; 10: 242253. Hulka CA, Edmister WB, Smith BL, et al. Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis. Radiology 1997; 205: 837 Buadu LD, Murakami J, Murayama S, et al. Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. Radiology 1996; 200: 639 Tofts PS, Berkowitz B, Schnall MD. Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a per!
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DRUGS AND FOODS TO AVOID: Ask your doctor or pharmacist before using any other medicine, including overthe-counter medicines, vitamins, and herbal products. Make sure your doctor knows if you are also using orphenadrine Norflex, Norgesic ; , cyclophosphamide Cytoxan ; , theophylline, Tagamet, levodopa Sinemet ; , diet pills appetite suppressants ; , other medicine for depression, medicine for anxiety such as diazepam, Valium ; , blood pressure medicine such as atenolol, metropolis, Toprol ; , medicines to treat mental illness such as haloperidol Haldol ; , thioridazine Mella5il , a steroid such as cortisone, prednisone ; , or medicine for heart rhythm problems such as verapamil, Rythmol, Tambocor ; . Do not drink alcohol while you are using this medicine. Tell your doctor if you currently drink alcohol or use other sedatives on a regular basis and mexiletine.
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Financial management and forecasting. Regular review, monitoring, and reporting of expenditures and revenues with additional emphasis on forecasting authorization balances through the end of the fiscal year. Budgeting. Annual preparation of the operating and capital budget request for the entire department. Periodic and final reconciliation of the annual budget authorization with actual expenditures and revenues. Budget analysis and forecasting. Fiscal and Accounting. Perform all accounting functions for the department through centralized accounts payable receivable, review and payment of professional services contracts; and federal grant reporting. Complete annual fiscal year closeout involving reconciliation of expenditures and revenues and ensure all fiscal year obligations are encumbered or satisfied before the end of the reappropriation period. Procurement. Manage the procurement process for outside legal counsel and expert contracts. Provide property control and centralized supply and equipment purchasing. Develop guidelines for leased space needs. Cost Allocation. Calculate and revise the federally approved cost allocation plan. Timekeeping & Billing. Calculate the department's attorney and paraprofessional timekeeping rate structure; manage the Civil Division's full-time attorney and paraprofessional time reporting and case management system; generate and monitor client billings; and respond to routine inquiries regarding individual matter, client, or project time and charges. Information Services. Provide computer hardware and software support to each of over 470 computer end-users located in Anchorage, Juneau, Fairbanks, Palmer, Kenai, Bethel, Ketchikan, Kodiak, Nome, Barrow, Dillingham, Kotzebue and Sitka. This support includes: network support, application maintenance and support, and hardware and software installation. In addition the Section provides individual assistance when necessary and presents occasional formal training. Other services provided by the section include web development, technical liaison on projects involving other public agencies, special projects, and service on statewide technical committees that establish the foundations for state government digital communication. Mail Services. Provide central mail pickup and delivery services for Juneau offices of the department as well as centralized mail services for certain legal and library supplies for the entire agency. Provide off-site security screening and and micardis.
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